Insulin-like growth factor I secreted from prostate stromal cells mediates tumor-stromal cell interactions of prostate cancer

Cancer Research
Manabu KawadaDaishiro Ikeda

Abstract

Prostate cancer shows high expression of type I insulin-like growth factor (IGF-I) receptor (IGF-IR) and prostate stromal cells (PrSC) produce IGF-I. Although high plasma level of IGF-I is a risk factor of prostate cancer, the significance of the prostate stromal IGF-I in the regulation of prostate cancer remains elusive. Here we show that the stromal IGF-I certainly regulates the development of prostate cancer. Coinoculation of PrSC increased the growth of human prostate cancer LNCaP and DU-145 tumors in severe combined immunodeficient mice. The conditioned medium of PrSC, as well as IGF-I, induced phosphorylation of IGF-IR and increased the growth of LNCaP and DU-145 cells. PrSC, but not LNCaP and DU-145 cells, secreted significant amounts of IGF-I. Coculture with PrSC increased the growth of DU-145 cells in vitro but the pretreatment of PrSC with small interfering RNA of IGF-I did not enhance it. Furthermore, various chemical inhibitors consisting of 79 compounds with approximately 60 different targets led to the finding that only IGF-IR inhibitor suppressed the PrSC-induced growth enhancement of DU-145 cells. Thus, these results show that the prostate stromal IGF-I mediates tumor-stromal cell interactions of prostate cancer...Continue Reading

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Citations

Jan 21, 2009·Cancer Metastasis Reviews·Otto SchmalhoferThomas Brabletz
Mar 14, 2009·The Journal of Antibiotics·Manabu KawadaDaishiro Ikeda
Feb 25, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kahina OussedikPaola B Arimondo
Mar 23, 2011·Biochemistry. Biokhimii︠a︡·S S ShishkinI N Krakhmaleva
Mar 30, 2011·Cancer Research·Diana RomeroCalvin P H Vary
Jan 20, 2009·World Journal of Gastroenterology : WJG·Laurie Drozdowski, Alan B R Thomson
Aug 11, 2010·FEBS Letters·Kaori HatsugaiHiroyuki Seimiya
Jan 6, 2009·Biochimica Et Biophysica Acta·Alba MinelliZoran Culig
Jan 3, 2007·Drug Discovery Today·Grant R ZimmermannCurtis T Keith
Apr 19, 2013·Organic Letters·Hikaru AbeMasakatsu Shibasaki
Nov 26, 2009·Molecular and Cellular Endocrinology·Massimiliano RuscicaPaolo Magni
Oct 30, 2013·Molecular and Cellular Biology·Takeharu SakamotoMotoharu Seiki
Jan 4, 2007·The Journal of Pathology·N SampsonP Berger
Oct 2, 2009·International Journal of Cancer. Journal International Du Cancer·Manabu KawadaDaishiro Ikeda
Dec 23, 2006·Expert Review of Vaccines·Johan Skog
Jun 2, 2015·Chemical & Pharmaceutical Bulletin·Hikaru AbeMasakatsu Shibasaki
Mar 8, 2020·International Journal of Cancer. Journal International Du Cancer·Tomokazu OhishiManabu Kawada
Apr 5, 2018·Journal of Clinical Medicine·Kenichiro IshiiMasatoshi Watanabe
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Aug 21, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaodong WangChristopher J Sweeney
Aug 19, 2007·The American Journal of Pathology·Wenhua LiAria F Olumi

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