Insulin-like growth factor (IGF)-I and -II and IGF-binding proteins-1, -2, and -3 in children and adolescents with diabetes mellitus: correlation with metabolic control and height attainment

The Journal of Clinical Endocrinology and Metabolism
B Strasser-VogelW Kiess

Abstract

The putative effects of diabetes and metabolic control on circulating levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) remain controversial. In the present study, serum levels of IGF-I and IGF-II and IGFBP-1, -2, and -3 were measured in 58 patients (age, 0.8-17 yr) with treated (51 subjects) or untreated (7 subjects) insulin-dependent diabetes mellitus (IDDM) and were compared with the levels in normal subjects. In the untreated patients IGF-I and IGF-II were decreased as compared with the healthy controls. In the treated diabetics IGF-I and IGF-II were reduced; IGFBP-2 (only in prepubertal subjects) and IGFBP-3 were increased. Furthermore, age-adjusted values of IGF-I, IGF-II, and IGFBP-3 were lower in prepubertal than in pubertal patients. Regression analysis revealed a negative correlation between hemoglobin (Hb)A1c and standard deviation scores (SDS) of IGF-I and a positive association between HbA1c and IGFBP-1 SDS or IGFBP-2 SDS. In the treated patients HbA1c was positively related to IGFBP-1 SDS and IGFBP-2 SDS when applying simple regression analysis and to IGFBP-2 SDS when using a multiple regression model. Strong correlations were observed between height SDS and IGF-I SDS, IGF-II SDS, an...Continue Reading

Citations

Jun 13, 2012·World Journal of Gastroenterology : WJG·Wei-Guang LiYong-Ping Zhang
Nov 3, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Andreas Hoeflich, Vincenzo C Russo
Oct 21, 1999·Molecular Genetics and Metabolism·L A WetterauP Cohen
Feb 7, 2001·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·B FeldmannB O Boehm
Dec 23, 2014·The Journal of Clinical Endocrinology and Metabolism·Jesper S SorensenUNKNOWN Danish Society for Diabetes in Childhood and Adolescence

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