Insulin-like growth factor (IGF)-I and IGF binding protein-3 concentrations in fluid from human stimulated follicles

Human Reproduction
G J OosterhuisJ Schoemaker

Abstract

Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) play an important role in regulating follicle growth and maturation. We have evaluated whether responsiveness to gonadotrophins during an in-vitro fertilization (IVF) treatment is related to follicular fluid IGF-I and IGFBP-3 concentrations. We also investigated if a difference is present in IGF-I and IGFBP-3 concentrations between patients treated with human menopausal gonadotrophin (HMG) and patients treated with highly purified follicle stimulating hormone (FSH). We have measured IGF-I and IGFBP-3 in follicular fluid from pre-ovulatory follicles in an IVF programme. All 70 patients were stimulated after being down-regulated with a gonadotrophin-releasing hormone (GnRH) analogue. IGF-I concentrations in follicular fluid were significantly inversely correlated with the number of ampoules FSH administered and number of days of FSH administration, and significantly correlated with the number of follicles aspirated. IGFBP-3 concentrations were not correlated with any other parameter measured nor were IGF-I and IGFBP-3 concentrations correlated. IGFBP-3 concentrations were significantly higher in patients receiving highly purified FSH compared with patients r...Continue Reading

Citations

Nov 24, 2007·Journal of Assisted Reproduction and Genetics·D LoutradisA Antsaklis
Feb 18, 2011·Journal of Assisted Reproduction and Genetics·Gulay GencLeyla Mollamahmutoglu
May 6, 2009·Reproductive Biology and Endocrinology : RB&E·Alberto RevelliPaolo Rinaudo
Nov 27, 2009·Systems Biology in Reproductive Medicine·Feng-Jing LiangYong Wang
Jan 31, 2016·Fertility and Sterility·Ernesto BoschDavid Meldrum
Feb 24, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ertan AdaliHanim Guler Sahin
Jan 7, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ozhan OzdemirCemal Resat Atalay
May 4, 2015·American Journal of Obstetrics and Gynecology·Ilana RamerSteven D Spandorfer
Jul 13, 1999·Human Reproduction·V Karande, N Gleicher
Mar 18, 2017·Current Opinion in Obstetrics & Gynecology·Roger J HartRobert J Norman
Mar 29, 2007·Reproduction, Fertility, and Development·Qiang Wang, Qing-Yuan Sun
Aug 10, 2019·Frontiers in Endocrinology·Roger J Hart
Nov 23, 2019·Journal of Assisted Reproduction and Genetics·Dimitrios NasioudisSteven D Spandorfer
Nov 15, 2020·Annals of the New York Academy of Sciences·Konstantinos SfakianoudisMara Simopoulou

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.