Abstract
Insulin-like growth factors (IGFs) are potent mitogens for breast cancer cells in vitro, and elevated IGF-I serum levels are a risk factor for breast malignancies. This study evaluated IGF-I and IGF-II serum levels in healthy women and in patients with benign and malignant breast lesions and correlated them with tumor size. Serum levels of the total and unbound fractions of IGF-I and IGF-II were analyzed in 65 patients with benign and malignant breast lesions and in 38 women without breast disease. ELISAs were used to detect serum IGF levels, with (total IGF) or without (free IGF) prior acid-ethanol extraction. Total IGF-I serum concentrations were lower in healthy women than in breast cancer patients (P < 0.001) or patients with benign breast lesions (P = 0.010), but no differences were observed in free IGF-I levels. Conversely, healthy women had higher serum levels of free IGF-II than women with breast lesions (P = 0.003), and the free/total IGF-II ratio was significantly reduced in patients with breast disease (P = 0.001). Although IGF-I or IGF-II serum concentrations of breast cancer patients were similar to those of patients with benign lesions, the size of a malignant tumor was correlated to the ratio free/total IGF-II (P...Continue Reading
References
Mar 1, 1991·Breast Cancer Research and Treatment·D YeeD R Powell
Nov 7, 1990·Journal of the National Cancer Institute·M PollakR Margolese
Jun 1, 1989·Annals of Internal Medicine·D F WilliamsonJ S Kendrick
Nov 1, 1986·The Journal of Clinical Endocrinology and Metabolism·D R PowellR L Hintz
Jul 28, 1995·International Journal of Cancer. Journal International Du Cancer·P F BruningA A Hart
Jan 1, 1995·Journal of Cancer Research and Clinical Oncology·R E FavoniL Miglietta
Feb 1, 1995·Endocrine Reviews·J I Jones, D R Clemmons
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J P PeyratA Demaille
May 1, 1996·Journal of the National Cancer Institute·R L RochaD Yee
May 10, 1996·The Journal of Biological Chemistry·K A QuinnF Cuttitta
Aug 1, 1997·Endocrine·Y Oh
Apr 16, 1998·The Journal of Biological Chemistry·S M Twigg, R C Baxter
Apr 4, 1998·Annals of Surgical Oncology·E H NgK O Lee
May 21, 1998·Lancet·S E HankinsonM Pollak
Mar 5, 1999·Breast Cancer Research and Treatment·M J EllisA Harris
Aug 12, 1999·The Australian and New Zealand Journal of Surgery·I M HoldawayI D Civil
Sep 1, 1999·The Journal of Endocrinology·S E BastianD A Belford
Sep 21, 2000·Journal of the National Cancer Institute·H Yu, T Rohan
Nov 10, 2000·International Journal of Cancer. Journal International Du Cancer·P TonioloA Zeleniuch-Jacquotte
Feb 24, 2001·Annals of Surgical Oncology·I M HoldawayI D Civil
Mar 27, 2001·International Journal of Cancer. Journal International Du Cancer·B D LiH Yu
Jul 5, 2001·British Journal of Cancer·S I HelleP E Lønning
Jul 20, 2001·British Journal of Cancer·S I HelleP E Lønning
Citations
Jul 15, 2009·Cancer Causes & Control : CCC·Benjamin B E BarnesKaren Steindorf
Oct 30, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GadducciR Tana
May 8, 2007·International Journal of Hematology·Francesco LandiGraziano Onder
May 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gil MorDavid C Ward
Mar 18, 2011·Growth Factors·A E RichardsonD De León
Feb 11, 2016·BMC Systems Biology·Dan TianPamela K Kreeger
Apr 13, 2010·Research in Veterinary Science·Felisbina L QueirogaJuan C Illera
Mar 27, 2007·Ophthalmology·Kyung-Chul YoonJin Choi
Jan 9, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Francesco LandiRoberto Bernabei
Dec 7, 2005·International Journal of Cancer. Journal International Du Cancer·Chu ChenDavid B Thomas
Apr 19, 2005·European Journal of Internal Medicine·R A BadawiL Kalra
Oct 9, 2015·International Journal of Endocrinology·Vinodh Kumar RadhakrishnanDaisy D De León
Sep 15, 2011·Growth Factors·S Kalla SinghD De León
Feb 24, 2015·Cytokine & Growth Factor Reviews·Jurriaan Brouwer-Visser, Gloria S Huang
Apr 16, 2015·BioMed Research International·Nalo HamiltonRichard Pietras
Nov 22, 2012·British Journal of Cancer·E SamoliP Lagiou
Feb 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Jyh-Ming LiouJaw-Town Lin
Oct 20, 2018·Oncotarget·David AustinJaydutt Vadgama
Jul 18, 2018·Frontiers in Pharmacology·Dan-Dan XuYi-Fei Wang
Jan 24, 2014·Molecular Cancer Research : MCR·Fayth L Miles, Robert A Sikes
May 4, 2012·Molecular Cancer Therapeutics·Weizao ChenDimiter S Dimitrov
Oct 19, 2006·Cancer Research·Yoko MitsuiYasunori Okada
Nov 21, 2020·Oncotarget·Vinodh Kumar RadhakrishnanDaisy D De León