Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-alpha activation via the mitogen-activated protein kinase pathway

Breast Cancer Research : BCR
G ThordarsonF Talamantes

Abstract

Pregnancy protects against breast cancer development in humans and rats. Parous rats have persistently reduced circulating levels of growth hormone, which may affect the activity of the growth hormone/insulin-like growth factor (IGF)-I axis. We investigated the effects of IGF-I on parity-associated protection against mammary cancer. Three groups of rats were evaluated in the present study: IGF-I-treated parous rats; parous rats that did not receive IGF-I treatment; and age-matched virgin animals, which also did not receive IGF-I treatment. Approximately 60 days after N-methyl-N-nitrosourea injection, IGF-I treatment was discontinued and all of the animal groups were implanted with a silastic capsule containing 17beta-estradiol and progesterone. The 17beta-estradiol plus progesterone treatment continued for 135 days, after which the animals were killed. IGF-I treatment of parous rats increased mammary tumor incidence to 83%, as compared with 16% in parous rats treated with 17beta-estradiol plus progesterone only. Tumor incidence and average number of tumors per animal did not differ between IGF-I-treated parous rats and age-matched virgin rats. At the time of N-methyl-N-nitrosourea exposure, DNA content was lowest but the alpha-...Continue Reading

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Citations

Jul 19, 2008·Breast Cancer Research and Treatment·Thangaiyan Rabi, Anupam Bishayee
Jan 30, 2007·Breast Cancer Research : BCR·Lakshmanaswamy RajkumarDaniel Medina
Oct 27, 2010·The Journal of Endocrinology·Rhone A MendozaGudmundur Thordarson
Dec 21, 2013·Trends in Molecular Medicine·Fabienne Meier-Abt, Mohamed Bentires-Alj
Jul 2, 2008·Obstetrics and Gynecology·Anne O RodriguezLloyd Smith
Jun 20, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Lesley Mathews, Sallie Smith Schneider
Jan 30, 2018·Frontiers in Oncology·Robin L AndersonKara L Britt
May 12, 2005·Journal of Mammary Gland Biology and Neoplasia·Agla Jael Rubner FridriksdottirOle William Petersen
May 12, 2005·Journal of Mammary Gland Biology and Neoplasia·Kay-Uwe Wagner, Gilbert H Smith
Oct 22, 2016·Oncotarget·Christina Gutierrez BracamontesRajkumar Lakshmanaswamy
Aug 20, 2017·Cancer Causes & Control : CCC·Mark J PowellChristopher C Benz
Feb 24, 2012·The Breast Journal·Sheikh Asim AliVictor Vogel

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Methods Mentioned

BETA
protein assay

Software Mentioned

ImageJ

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