Insulin-like growth factor II (IGF-II) is more potent than IGF-I in stimulating cortisol secretion from cultured bovine adrenocortical cells: interaction with the IGF-I receptor and IGF-binding proteins

Endocrinology
M M WeberD Engelhardt

Abstract

Although the stimulating effect of insulin-like growth factor I (IGF-I) on adrenal steroidogenesis has been well established, the role of IGF-II in the adult adrenal gland remains unknown. We, therefore, investigated the effect of recombinant human IGF-II on cortisol and cAMP synthesis from adult bovine adrenocortical cells. IGF-II, time and dose dependently, stimulated basal cortisol secretion maximally 3-fold. In combination with ACTH, IGF-II (13 nM) synergistically increased cortisol secretion from 1-fold (10(-8) M ACTH) to 28-fold of untreated control levels. In contrast, IGF-I at equimolar concentrations did not show an effect on basal cortisol secretion, and in combination with ACTH elicited a significant weaker stimulatory effect than IGF-II (22-fold increase). The synergistic effect of IGF-II on ACTH-promoted cortisol secretion was paralleled by accumulation of cAMP in the culture medium. Although both IGF receptors are present in adult bovine adrenocortical cells, the effect of IGF-II seems to be mediated through interaction with the IGF-I receptor, as [Arg54,55]IGF-II, which only binds to the IGF-I receptor, was equipotent to native IGF-II, whereas [Leu27]IGF-II, which preferentially binds to the type II IGF receptor,...Continue Reading

Citations

Nov 1, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Jianhua HuangShijin Xia
Oct 25, 2011·Molecular and Cellular Endocrinology·Tamaya Castro Ribeiro, Ana Claudia Latronico
Oct 27, 2004·Molecular and Cellular Endocrinology·L J SpicerD T Allen
Dec 8, 2015·International Journal of Cancer. Journal International Du Cancer·Barbara AltieriGiovanna Muscogiuri
Apr 3, 2001·European Journal of Clinical Investigation·M M WeberE Wolf
Jul 3, 2018·Minerva endocrinologica·Barbara AltieriAntongiulio Faggiano
May 7, 1998·Endocrine Reviews·M Ehrhart-BornsteinG P Vinson
Aug 29, 2012·Journal of Oncology·Roberta MalaguarneraAntonino Belfiore
Sep 9, 2006·Endocrinology·Delia SilvaMary Frances Lopez

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