Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse

The Journal of Pathology
L J HaleR J Coward

Abstract

Podocytes are crucial for preventing the passage of albumin into the urine and, when lost, are associated with the development of albuminuria, renal failure and cardiovascular disease. Podocytes have limited capacity to regenerate, therefore pro-survival mechanisms are critically important. Insulin-like growth factor-II (IGF-II) is a potent survival and growth factor; however, its major function is thought to be in prenatal development, when circulating levels are high. IGF-II has only previously been reported to continue to be expressed in discrete regions of the brain into adulthood in rodents, with systemic levels being undetectable. Using conditionally immortalized human and ex vivo adult mouse cells of the glomerulus, we demonstrated the podocyte to be the major glomerular source and target of IGF-II; it signals to this cell via the IGF-I receptor via the PI3 kinase and MAPK pathways. Functionally, a reduction in IGF signalling causes podocyte cell death in vitro and glomerular disease in vivo in an aged IGF-II transgenic mouse that produces approximately 60% of IGF-II due to a lack of the P2 promoter of this gene. Collectively, this work reveals the fundamental importance of IGF-II in the mature podocyte for glomerular he...Continue Reading

References

Feb 22, 1991·Cell·T M DeChiaraA Efstratiadis
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A J D'ErcoleL E Underwood
Apr 1, 1995·Endocrine Reviews·D LeRoithC T Roberts
Feb 1, 1995·Endocrine Reviews·J I Jones, D R Clemmons
Jan 15, 1997·The Journal of Clinical Investigation·M E PagtalunanT W Meyer
Feb 1, 1997·Molecular Human Reproduction·A Ward
Oct 23, 1997·Science·S W LambertsA J van der Lely
Feb 22, 2002·Journal of the American Society of Nephrology : JASN·Moin A SaleemPeter Mundel
Jun 18, 2002·The Lancet Oncology·Gregor Fürstenberger, Hans-Jörg Senn
Aug 15, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Jane J Kim, Domenico Accili
Dec 31, 2002·Physiological Reviews·Hermann PavenstädtMatthias Kretzler
Sep 5, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Darren J Bridgewater, Douglas G Matsell
Mar 11, 2005·Journal of the American Society of Nephrology : JASN·Taiji MatsusakaIekuni Ichikawa
Mar 23, 2005·Kidney International·Darren J BridgewaterDouglas G Matsell
Aug 11, 2005·Current HIV/AIDS Reports·Ruth Berggren, Vecihi Batuman
Oct 27, 2005·Diabetes·Richard J M CowardMoin A Saleem
Jan 27, 2006·Journal of the American Society of Nephrology : JASN·Vera EreminaSusan E Quaggin
Aug 11, 2006·Journal of the American Society of Nephrology : JASN·Nynke HalbesmaRonald T Gansevoort
Oct 19, 2006·Neuroendocrinology·Jeff Holly, Claire Perks
Aug 11, 2007·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Darren J BridgewaterDouglas G Matsell
May 10, 2008·Archives of Physiology and Biochemistry·Haim WernerItay Bentov
Jul 29, 2008·Current Opinion in Nephrology and Hypertension·Peter J LavinMichelle P Winn
May 28, 2009·Journal of the American Society of Nephrology : JASN·Detlef Schlöndorff, Bernhard Banas
Oct 5, 2010·Cell Metabolism·Gavin I WelshRichard J M Coward
May 25, 2011·The Journal of Clinical Investigation·Marie JeanssonSusan E Quaggin
Jun 10, 2011·American Journal of Physiology. Renal Physiology·Ramadan M SarrabMoin A Saleem
Oct 26, 2011·Nature Reviews. Nephrology·Gavin I Welsh, Moin A Saleem
Nov 30, 2011·Current Opinion in Nephrology and Hypertension·Leon A Bach
Dec 6, 2011·Growth Factors·Lynda K Harris, Melissa Westwood

❮ Previous
Next ❯

Citations

Jan 8, 2014·Nature Reviews. Nephrology·Jochen ReiserChristian Faul
May 2, 2014·Advances in Chronic Kidney Disease·Frank C Brosius, Richard J Coward
Sep 20, 2015·Biochimica Et Biophysica Acta·Beatriz SantamariaÁngela M Valverde
Aug 26, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Leon A Bach, Lorna J Hale
Jun 23, 2016·International Journal of Molecular Sciences·Feng Liu, Shougang Zhuang
Aug 16, 2016·The Journal of Endocrinology·Diane DoneganCheryl A Conover
Jun 12, 2018·DNA and Cell Biology·Eliecer CotoPablo Coto-Segura
Feb 27, 2016·F1000Research·Jochen Reiser, Mehmet M Altintas
Nov 22, 2014·Current Opinion in Nephrology and Hypertension·Richard Coward, Alessia Fornoni
May 24, 2013·American Journal of Physiology. Renal Physiology·L J HaleR J Coward
Nov 21, 2014·American Journal of Physiology. Renal Physiology·Jia FuJohn Cijiang He

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.