Insulin-like growth factor receptor type I as a target for cancer therapy

Immunotherapy
Liliane Goetsch, Nathalie Corvaia

Abstract

In recent years, improvements in the understanding of oncogenesis has permitted the identification of new molecular targets for cancer therapy. Among all the different approaches, inhibition of tyrosine kinase receptor activity using small molecules or biomolecules for controlling cancer growth has been successful and has brought new therapeutic opportunities to the medical community. After more than 20 years of extensive work, insulin-like growth factor receptor I (IGF-IR) is becoming an attractive target for drug development. Owing to its close homology to insulin receptor, IGF-IR is of interest for antibody design while its specificity allows us to discriminate between the two receptors. Major efforts from a large number of pharmaceutical companies are invested in evaluating the efficacy of such molecules in humans. Discovery of biomarkers associated with efficacy and patient selection are the main challenges that we will have to deal with in order to target the appropriate patient population that will most benefit from anti-IGF-IR monoclonal antibodies and combined treatments. This review will provide an overview of the current knowledge on IGF-IR and ongoing clinical trials.

References

Jun 15, 1989·Cancer·M J Wizenberg
Jan 1, 1994·Hormone Research·K SiddleB T Navé
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C SellR Baserga
Jan 1, 1996·Journal of Cellular Biochemistry. Supplement·F ZiaT W Moody
Jun 7, 1997·Biochimica Et Biophysica Acta·R BasergaB Valentinis
Jan 29, 1999·Journal of the National Cancer Institute·H YuX Wu
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·S YakarD LeRoith
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·J DiGiovanniC Conti
Apr 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D W AndrewsR D Aiken
Nov 6, 2001·Nature Structural Biology·S FavelyukisW T Miller
Dec 26, 2001·Journal of the National Cancer Institute·J Albanell, J Baselga
Dec 26, 2001·Journal of the National Cancer Institute·Y LuM Pollak
Oct 3, 2002·Nature Reviews. Drug Discovery·Pierre De Meyts, Jonathan Whittaker
Jan 28, 2003·Cancer·Marco SantucciUNKNOWN EORTC Cutaneous Lymphoma Task Force
Jul 19, 2003·The Journal of Biological Chemistry·Galia BlumAlexander Levitzki
Sep 25, 2003·Human Pathology·Abderrahman OubanDomenico Coppola
Nov 6, 2003·International Journal of Cancer. Journal International Du Cancer·Renato BasergaKrysztof Reiss
Nov 15, 2003·The Journal of Biological Chemistry·Deepali SachdevDouglas Yee
Jan 8, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A DenleyB E Forbes
Jan 8, 2004·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·D ZhangP Brodt
Mar 31, 2004·Cancer Cell·Carlos García-EcheverríaFrancesco Hofmann
May 22, 2004·Annals of the New York Academy of Sciences·Rachel B HazanKimita Suyama

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Methods Mentioned

BETA
transgenic
antisense oligonucleotides
xenograft
biopsy
xenografts
biopsies

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