Insulin-like growth factor signaling regulates developmental trajectory associated with diapause in embryos of the annual killifish Austrofundulus limnaeus

The Journal of Experimental Biology
S Cody Woll, J E Podrabsky

Abstract

Annual killifishes exhibit a number of unique life history characters including the occurrence of embryonic diapause, unique cell movements associated with dispersion and subsequent reaggregation of the embryonic blastomeres, and a short post-embryonic life span. Insulin-like growth factor (IGF) signaling is known to play a role in the regulation of metabolic dormancy in a number of animals but has not been explored in annual killifishes. The abundance of IGF proteins during development and the developmental effects of blocking IGF signaling by pharmacological inhibition of the insulin-like growth factor I receptor (IGF1R) were explored in embryos of the annual killifish Austrofundulus limnaeus Blocking of IGF signaling in embryos that would normally escape entrance into diapause resulted in a phenotype that was remarkably similar to that of embryos entering diapause. IGF-I protein abundance spikes during early development in embryos that will not enter diapause. In contrast, IGF-I levels remain low during early development in embryos that will enter diapause II. IGF-II protein is packaged at higher levels in escape-bound embryos compared with diapause-bound embryos. However, IGF-II levels quickly decrease and remain low during...Continue Reading

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Citations

Nov 18, 2018·Proceedings of the National Academy of Sciences of the United States of America·Amie L T RomneyJason E Podrabsky
Nov 30, 2018·Proceedings of the National Academy of Sciences of the United States of America·Christoph Englert
Jan 9, 2019·ELife·Martin Reichard, Matej Polačik
Sep 8, 2018·Scientific Reports·Amie L T Romney, Jason E Podrabsky
Apr 16, 2020·Science China. Life Sciences·Tahir MuhammadZi-Jiang Chen
Aug 30, 2020·The Journal of Experimental Biology·Daniel E Zajic, Jason E Podrabsky

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