Insulin-like growth factors and their binding proteins in the ovine oviduct during the oestrous cycle

Journal of Reproduction and Fertility
K R Stevenson, D C Wathes

Abstract

The oviduct is the site of fertilization, and factors present in the oviductal fluid appear to be crucial to the future success of conceptus development. The spatial and temporal localization of mRNA encoding components of the insulin-like growth factor (IGF) system (IGF-I, IGF-II, the type 1 IGF receptor, and IGF-binding proteins -2, -3 and -4) in the ovine oviduct were examined in tissue samples taken during the early and late stages of follicular development, and the early, mid-, and late luteal phases using in situ hybridization. Expression of mRNA encoding IGF-I showed a cyclical pattern, increasing sharply in the mucosa and muscularis during the late follicular phase (P < or = 0.001), then declining. In the muscularis, mRNA encoding IGF-II exhibited no temporal changes, but concentrations in the mucosa increased from the late follicular stage to the early luteal phase. mRNA encoding the type 1 IGF receptor was present throughout the oviduct. Concentrations increased during the follicular phase to peak in the early luteal phase in both the mucosa and muscularis (P < 0.001). IGFBP-2 gene transcripts were undetectable at all time points examined. mRNAs encoding IGFBP-3 and IGFBP-4 were localized primarily in the stromal regi...Continue Reading

Citations

Apr 15, 2000·Domestic Animal Endocrinology·T HashizumeN Matsumoto
Jul 7, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Theerawat Swangchan-UthaiD Claire Wathes
Dec 27, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·M A FenwickD C Wathes
Apr 20, 2016·Theriogenology·Waleed F A MareiAli A Fouladi-Nashta
May 25, 2005·Animal Reproduction Science·S P QuigleyS K Walker
Sep 1, 2012·Reproduction, Fertility, and Development·Roberta Nogueira ChavesJosé Ricardo de Figueiredo
Feb 18, 2004·The Journal of Reproduction and Development·Sumie NonakaShigeo Hara

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