PMID: 7525829Oct 1, 1994Paper

Insulin-like growth factors-I and -II and their binding proteins during postnatal development of dwarf Snell mice before and during growth hormone and thyroxine therapy

The Journal of Endocrinology
S C van Buul-OffersJ L Van den Brande

Abstract

The ontogeny of serum insulin-like growth factors (IGFs)-I and -II and their binding proteins (IGFBPs) was studied in normal and dwarf Snell mice. IGF-I concentrations in serum of normal mice increased between 4 and 8 weeks of age; dwarf mice had very low serum IGF-I levels. In both normals and dwarfs, serum IGF-II levels were highest soon after birth and dropped steadily thereafter. Western ligand blots of serum IGFBPs with 125I-IGF-II as tracer revealed the expected bands of 41.5, 38.5, 30-32 and 24 kDa. In normal mice the IGFBP-3 doublet was already detectable at 2 weeks of age, and its intensity increased with age. In dwarf mice the IGFBP-3 doublet was hardly detectable. The changes of IGFs and their IGFBPs were studied in sera of dwarf mice after treatment with growth hormone (GH) and/or thyroxine (T4) for 4 weeks. In spite of a comparable growth response obtained using these hormones, serum IGF-I was increased only by GH treatment; a small but significant decrease of serum IGF-II was obtained following GH or T4 treatment. An increase of the IGFBP-3 doublet was only obtained with GH; T4 and GH + T4 had no effect. The rise of IGFBP-3 after GH treatment was accompanied by the formation of the IGFBP 150 kDa complex, as measur...Continue Reading

Citations

May 25, 1999·General and Comparative Endocrinology·C G ScanesS V Radecki
Dec 24, 2018·Endocrine Reviews·Manuel H Aguiar-Oliveira, Andrzej Bartke
Apr 17, 2013·Physiological Reviews·Andrzej BartkeValter Longo
Aug 20, 2019·Aging Cell·Ulas Ozkurede, Richard A Miller
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·C ArpinJ Marvel
Dec 6, 2020·Molecular and Cellular Endocrinology·S Thierry OmouessiRichard R Neubig

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