Insulin-like growth factors (IGF)-I and -II and IGF binding protein-1, -2, and -3 in patients with acromegaly before and after adenomectomy

Metabolism: Clinical and Experimental
J O JørgensenW F Blum

Abstract

The interrelationship between insulin-like growth factors (IGFs) and their major binding proteins (IGFBPs) as a function of disease activity in acromegaly has not previously been prospectively evaluated. We studied basal and insulin-stimulated serum levels of IGF-I and -II and IGFBP-1, -2, and -3 in six acromegalic patients before and 2 months after successful adenomectomy compared with a group of sex- and age-matched healthy, untreated subjects. All were studied postabsorptively (11 AM) and at the end of a 2-hour euglycemic glucose clamp (0.4 mU insulin/kg x min). Serum IGF-I levels (mean +/- SE) were elevated in acromegaly but were normalized following therapy (basal state IGF-I [micrograms/L], 857 +/- 119 [active] v 255 +/- 65 [postoperative] v 190 +/- 20 [control]). Serum IGF-II levels did not change following therapy and were similar to those of the control group. IGF levels did not change during the clamp. Serum IGFBP-3 levels were elevated in active acromegaly, but were normalized after therapy (basal state IGFBP-3 [micrograms/L] 6,983 +/- 612 [active] v 3,939 +/- 504 [postop] v 3,358 +/- 125 [control]). The molar ratio of (IGF-I+IGF-II): IGFBP-3 was similar in all studies. Serum IGFBP-1 interacted significantly with tim...Continue Reading

References

Nov 22, 1979·The New England Journal of Medicine·D R ClemmonsL E Underwood
Sep 1, 1977·The Journal of Clinical Investigation·R W FurlanettoA J D'Ercole
May 1, 1992·The Journal of Clinical Endocrinology and Metabolism
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·C A Conover, P D Lee
Oct 11, 1991·The Journal of Clinical Endocrinology and Metabolism·D R ClemmonsW H Busby
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J ZapfE R Froesch

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Citations

Jan 1, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Craig ParkinsonPeter J Trainer
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Pamela U Freda
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Oct 1, 1995·Clinical Endocrinology·W W de HerderS W Lamberts
Jul 1, 1996·Postgraduate Medical Journal·W W de HerderS W Lamberts
Nov 4, 2010·European Journal of Endocrinology·Sebastian J NeggersAart J van der Lely
Mar 6, 2007·Endocrinology and Metabolism Clinics of North America·David R Clemmons
Nov 3, 2015·Best Practice & Research. Clinical Endocrinology & Metabolism·Andreas Hoeflich, Vincenzo C Russo
Nov 3, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Thor Ueland
Jul 15, 2015·Molecular Oncology·Manojkumar BupathiAung Naing
Apr 20, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·H NørrelundJ O Jørgensen
Mar 27, 2002·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·S B SneppenU Feldt-Rasmussen
Jan 3, 2001·Biology of Reproduction·O J GintherK Kot
Mar 29, 2007·The Journal of Clinical Endocrinology and Metabolism·René Klinkby StøvingJan Frystyk
Apr 9, 1999·Journal of Endocrinological Investigation·H S Chen, H D Lin

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