Insulin-like growth factors (IGFs), IGF binding proteins, and other endocrine factors in milk: role in the newborn

Advances in Experimental Medicine and Biology
J W Blum, C R Baumrucker

Abstract

The role of colostrum and milk in the neonate has been chiefly recognized as a comprehensive nutrient foodstuff. In addition, the provision of colostrum-the first milk-for early immune capacity has been well documented for several species. Colostrum is additionally a rich and concentrated source of various factors that demonstrate biological activity in vitro. Three hypotheses have been proposed for the phenotypic function of these secreted bioactive components: (1) only mammary disposal, (2) mammary cell regulation, and (3) neonatal function [gastrointestinal tract (GIT) or systemic]. Traditionally, it was assumed that the development of the GIT is preprogrammed and not influenced by events occurring in the intestinal lumen. However, a large volume of research has demonstrated that colostrum (or milk-borne) bioactive components can basically contribute to the regulation of GIT growth and differentiation, while their role in postnatal development at physiological concentrations has remained elusive. Much of our current understanding is derived from cell culture and laboratory animals, but experimentation with agriculturally important species is taking place. This chapter provides an overview of work conducted primarily in neona...Continue Reading

Citations

May 27, 2010·Nutrition Research Reviews·Paul GuilloteauCornelia C Metges
Jul 1, 2010·Animal : an International Journal of Animal Bioscience·E E ConnorC Li
Sep 5, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·N A RodriguezJ M Zeller
Jul 31, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Meredith E CampCarol A Bagnell
Apr 14, 2017·Molecular Reproduction and Development·Carol A BagnellFrank F Bartol
Oct 19, 2017·Journal of Developmental Origins of Health and Disease·N TayJ P Buschdorf
Feb 27, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Bodo Melnik
Jan 29, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·B Melnik
Jan 30, 2014·Journal of Mammary Gland Biology and Neoplasia·Craig R Baumrucker, Rupert M Bruckmaier
Feb 7, 2020·Animal : an International Journal of Animal Bioscience·H M HammonC Koch
Oct 27, 2012·Journal of Animal Science·F F BartolC A Bagnell
Apr 19, 2015·Current Opinion in Infectious Diseases·Mathilde Turfkruyer, Valerie Verhasselt
Nov 1, 2018·Journal of Animal Science and Biotechnology·Shihai ZhangWutai Guan
Dec 10, 2017·Best Practice & Research. Clinical Endocrinology & Metabolism·Andreas Hoeflich, Zianka Meyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.