PMID: 19912843Feb 1, 1992Paper

Insulin-like growth factors in the response to cerebral ischemia

Molecular and Cellular Neurosciences
W H LeeC A Bondy

Abstract

Insulin-like growth factors-I and -II (IGF-I and -II) and their receptors are present in the central nervous system but their role in brain function is unknown. To elucidate this issue, we investigated the cellular pattern of expression for IGF-I and -II, their receptors, and binding proteins using in situ hybridization and immunocytochemistry in the setting of experimental focal cortical ischemia. There was a striking increase in both IGF-I and IGF-II gene expression in the ischemic cerebral cortex, but the two mRNAs were found in different cell populations. IGF-I mRNA was localized in reactive astrocytes that also stained intensely for glial fibrillary acidic protein (GFAP). IGF-II mRNA and immunoreactivity were contained in activated macrophages, which were highly abundant in the infarct zone and also in the meninges, blood vessels, and choroid plexus of the ischemic brain. High levels of IGF binding protein 2 mRNA were colocalized with IGF-II in these activated macrophages. Type-I IGF receptor mRNA was widely distributed in the affected area and type-II IGF receptor mRNA was also widely expressed but was particularly concentrated in macrophages. These findings suggest that the IGFs are involved in the brain's inflammatory r...Continue Reading

References

Apr 11, 1991·Brain Research. Molecular Brain Research·M A BachD LeRoith
Jan 1, 1991·Glia·M E HattenC A Mason
Jul 1, 1991·Journal of Neuroscience Research·S KomolyK F Chan
Jan 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R Rischke, J Krieglstein
Jul 5, 1990·European Journal of Biochemistry·R E Humbel
Nov 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C K PetitoM L Lesser
Jun 1, 1988·Trends in Neurosciences·V H Perry, S Gordon
Feb 1, 1988·Acta Physiologica Scandinavica·I K AnderssonH A Hansson
Apr 1, 1988·Brain Research·F L Jordan, W E Thomas
Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S BrintW Pulsinelli
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·F StylianopoulouA Efstratiadis
Jan 1, 1987·Immunobiology·T SminiaC H Polman
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Nov 1, 1990·Trends in Endocrinology and Metabolism : TEM·D R Clemmons

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Citations

Jan 1, 1994·Journal of Neural Transmission. General Section·A AdemV Sara
Dec 1, 1996·Molecular Neurobiology·A J D'ErcoleG Gutierrez-Ospina
Aug 1, 1994·Molecular Neurobiology·A AdemP G Gillberg
Sep 1, 1993·Trends in Pharmacological Sciences·A Logan, M Berry
Dec 10, 1993·Regulatory Peptides·G F JinC W Houston
Jun 1, 1996·Brain Research. Molecular Brain Research·A C Sandberg NordqvistM Schalling
Oct 22, 2003·Progress in Neurobiology·J GuanA J Gunn
Feb 20, 1997·Brain Research. Developmental Brain Research·W ZhangW H Lee
Mar 12, 1998·Brain Research. Molecular Brain Research·W C WallaceB Wolozin
Oct 16, 1999·Brain Research. Molecular Brain Research·S PeterssonC Lavebratt
Jan 1, 1997·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·W Zumkeller
May 28, 1993·Annals of the New York Academy of Sciences·W H Lee, C Bondy
Aug 27, 1993·Annals of the New York Academy of Sciences·C A Bondy, W H Lee
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·S KarR Quirion
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·S A LoddickE B De Souza
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·C M ChengC A Bondy
Mar 16, 2013·Acta neurochirurgica·Maria ZetterlingElisabeth Ronne-Engström
Jun 20, 2012·Frontiers in Neuroendocrinology·John O'Kusky, Ping Ye
Mar 29, 2014·Biochimica Et Biophysica Acta·Elisa Martin-MontañezMaria Garcia-Fernandez
Apr 20, 2004·European Journal of Pharmacology·Carolyn A Bondy, Clara M Cheng
Aug 27, 2016·Scientific Reports·Yu SongYevgeny Berdichevsky

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