PMID: 11322992Apr 27, 2001Paper

Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans

Mechanisms of Ageing and Development
Bart P BraeckmanJacques R Vanfleteren

Abstract

The nervous system acts as a major regulator of the life span of Caenorhabditis elegans. Temperature and chemical stimuli from the environment are integrated with internal signals from the reproductive system to specify adult longevity. An insulin-like signaling cascade acts in neurons and coordinates control of senescence of the entire organism by regulating metabolism and a stress response mechanism. Caloric restriction extends life span, possibly by activation of the stress response program.

References

Dec 3, 1992·Nature·W A Van Voorhies
Apr 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T B Kirkwood, M R Rose
Mar 1, 1989·Developmental Biology·W G Wadsworth, D L Riddle
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·T E Johnson, W B Wood
Dec 2, 1993·Nature·C KenyonR Tabtiang
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P L Larsen
Feb 9, 1996·The Journal of Biological Chemistry·B N Marbois, C F Clarke
Jul 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J R Vanfleteren, A De Vreese
Feb 4, 1998·Trends in Genetics : TIG·S HekimiJ J Ewbank
Mar 7, 1998·The Journal of Biological Chemistry·T JonassenC F Clarke
Jun 17, 1998·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·M FujiiD Ayusawa
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·B Lakowski, S Hekimi
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·V T MihaylovaH Sun
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·H A TissenbaumG Ruvkun
Jan 19, 2000·Neurobiology of Aging·J R Vanfleteren, B P Braeckman
Jan 29, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R BranickyS Hekimi
Mar 5, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H AdachiN Ishii
Apr 1, 2000·Journal of the American Aging Association·B P BraeckmanJ R Vanfleteren

❮ Previous
Next ❯

Citations

May 9, 2009·Age·L J Furness, J R Speakman
Jun 7, 2005·Mechanisms of Ageing and Development·Linda PartridgeWilliam Mair
Nov 8, 2003·Trends in Molecular Medicine·Arjan B Brenkman, Boudewijn M T Burgering
Feb 19, 2002·International Journal for Parasitology·Melissa J Beall, Edward J Pearce
May 29, 2002·Free Radical Biology & Medicine·Reshma Shringarpure, Kelvin J A Davies
Jun 18, 2002·Ageing Research Reviews·Kurt Heininger
Aug 8, 2002·The Plant Journal : for Cell and Molecular Biology·Hye Ryun WooHong Gil Nam
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alina BerdichevskyH Robert Horvitz
Aug 12, 2010·Antioxidants & Redox Signaling·Ricki J Colman, Rozalyn M Anderson
Jan 14, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Tapiwanashe MagwereLinda Partridge
Aug 13, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joanna Joyner-MatosCharles F Baer
Oct 14, 2009·Molecular and Cellular Biology·Justin R DiAngelo, Morris J Birnbaum
Nov 29, 2005·PLoS Genetics·Matt KaeberleinBrian K Kennedy
Mar 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Seung Wook OhHeidi A Tissenbaum
Jan 7, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ankita BansalHeidi A Tissenbaum
Feb 20, 2002·FEBS Letters·Hiroko MiyaderaKiyoshi Kita
Dec 30, 2008·Trends in Cell Biology·Veena Prahlad, Richard I Morimoto
Nov 26, 2015·Biochemical and Biophysical Research Communications·Jiaolong ZhangLijun Zhou
Aug 23, 2008·Insect Biochemistry and Molecular Biology·Benjamin M Pri-TalMichael A Riehle
Jan 1, 2008·Molecular and Cellular Endocrinology·Paul LaissueMarc Fellous
Apr 3, 2007·Molecular Aspects of Medicine·Bor Luen Tang, Christelle En Lin Chua
Jul 11, 2006·Experimental Gerontology·Bart P Braeckman, Jacques R Vanfleteren
May 17, 2005·Mechanisms of Ageing and Development·David A Sinclair
Jan 24, 2015·General and Comparative Endocrinology·Dick R NässelJiangnan Luo
Sep 15, 2007·Biochemical and Biophysical Research Communications·Manabu TsudaToshiro Aigaki
Jul 29, 2003·Aging Cell·Joshua McElweeJames H Thomas
May 15, 2002·Current Biology : CB·Scott D PletcherLinda Partridge
Jan 10, 2002·Developmental Cell·Heidi A Tissenbaum, Leonard Guarente
Nov 1, 2005·Developmental Cell·Mohan ViswanathanLeonard Guarente
Mar 5, 2009·Biochemical and Biophysical Research Communications·Hong LiuRen-Li Zhang
Aug 27, 2005·Diabetes Care·Zachary T Bloomgarden
Aug 29, 2006·Experimental Gerontology·Coleen T Murphy
Jun 26, 2018·Integrative and Comparative Biology·Steven N Austad
Jun 15, 2007·Nature Chemical Biology·Rebecca A ButcherJon Clardy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.