PMID: 8950298Jan 1, 1996Paper

Insulin-like vs. non-insulin-like stimulation of glucose metabolism by vanadium, tungsten, and selenium compounds in rat muscle

Life Sciences
C FürnsinnW Waldhäusl

Abstract

The direct impact of vanadate, tungstate, selenate, and selenite on glucose metabolism of isolated rat soleus muscle was investigated. All compounds stimulated glucose transport, but only vanadate exerted an insulin-like effect on glycogen synthesis (mumol glucose into glycogen*g-1*h-1: control 1.43 +/- 0.11 vs. 1 mmol/l vanadate, 2.08 +/- 0.11, p < 0.0001), which was more distinct in the presence of 1 mmol/l H2O2 (control, 1.44 +/- 0.13 vs. 1 mmol/l vanadate, 3.49 +/- 0.12, p < 0.001). Glucose handling of muscles exposed to tungstate, selenate, or selenite resembled that of hypoxic muscle, i.e. the induced rise in glucose uptake was inhibited by dantrolene and associated with high rates of glycolysis and rapid glycogen depletion (glycogen content after incubation, mumol glucosyl units/g: control, 16.2 +/- 0.7 vs. hypoxia, 2.7 +/- 0.5, p < 0.0001; control, 17.0 +/- 0.5 vs. 100 mmol/l tungstate, 5.5 +/- 0.4, p < 0.001; control, 16.2 +/- 0.7 vs. 100 mmol/l selenate, 1.5 +/- 0.3, and vs. 300 mumol/l selenite, 1.7 +/- 0.3, p < 0.0001 each). The results suggest that vanadate (and more pronounced it's peroxides) exerts true insulin-like action on isolated muscle glucose metabolism, whereas tungsten and selenium salts trigger glucose ...Continue Reading

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Citations

Oct 6, 2007·Biological Trace Element Research·Zubeyde ErbayraktarCanan Coker
Feb 24, 2010·Biological Trace Element Research·Yukisumi IizukaEiichi Sakurai
Jan 8, 1998·British Journal of Pharmacology·C FürnsinnW Waldhäusl
Sep 23, 2003·Nucleic Acids Research·Noam KaplanMichal Linial
Dec 21, 2004·Diabetic Medicine : a Journal of the British Diabetic Association·A K Srivastava, M Z Mehdi
Sep 23, 2010·BMC Public Health·Saverio StrangesVittorio Krogh
Nov 7, 2009·Reviews on Environmental Health·Marco VincetiCarlotta Malagoli
Jun 1, 2001·Journal of Endocrinological Investigation·R Perfetti, K Chamie
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·James P McClungXin Gen Lei
Sep 18, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Dan WeiWenjun Ding
Nov 26, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·S StrangesE Guallar
Jul 5, 2012·Molecular Nutrition & Food Research·Stéphane TanguyFrançois Boucher
Jul 23, 2013·Free Radical Biology & Medicine·Jun ZhouXin Gen Lei
Feb 22, 2012·Free Radical Biology & Medicine·Min-Shu ZengXin Gen Lei
Nov 15, 2000·Canadian Journal of Physiology and Pharmacology·M C CamJ H McNeill
May 16, 2012·Journal of Animal Science·M Y El-MokademA M Yassen
Feb 25, 2011·American Journal of Physiology. Cell Physiology·Barbara BrunmairClemens Fürnsinn
Jul 7, 2019·Theriogenology·M M Mojapelo, K C Lehloenya
Apr 23, 2005·Toxicology and Applied Pharmacology·Christy C Bridges, Rudolfs K Zalups
Apr 19, 2005·Journal of Inorganic Biochemistry·Anna M KordowiakWojciech Dabros

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