Insulin-mediated hypoglycaemia secondary to recurrent clear cell renal carcinoma

The Journal of the Royal College of Physicians of Edinburgh
G GognaP Bilinski

Abstract

Renal cell carcinoma has previously been associated with hypoglycaemia in the setting of non-islet cell tumours, caused by a paraneoplastic phenomenon relating to the production of insulin-like growth factor type II. We present a case of recurrent clear cell renal cell carcinoma, leading to an insulin-mediated paraneoplastic phenomenon causing severe recurrent hypoglycaemia. Hypoglycaemina was managed successfully using diazoxide therapy, in conjunction with pazopanib and radiotherapy to reduce tumour burden.

Citations

Aug 8, 2018·Journal of Veterinary Internal Medicine·M AlemanP H Kass
May 16, 2020·Annales d'endocrinologie·Claire DouillardMarie-Christine Vantyghem

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