PMID: 8946331Nov 6, 1996Paper

Insulin microinjection into the nucleus tractus solitarii of the rat attenuates the baroreceptor reflex

Journal of the Autonomic Nervous System
A M McKernan, F R Calaresu

Abstract

The presence of insulin and insulin binding sites in the central nervous system and the demonstration that central insulin has an effect on cardiovascular function has led to the hypothesis that insulin may play a role in mediating the baroreceptor reflex. To investigate this possibility, insulin was microinjected into depressor sites in the nucleus tractus solitarius (NTS), the first central synapse of the baroreceptor reflex, of urethane anesthetized rats. Microinjection of insulin into the NTS (110 nL of 1, 10 and 100 IU/mL) did not change mean arterial pressure (MAP) or heart rate (HR). However, insulin microinjection attenuated phenylephrine-elicited reflex bradycardia and depressor responses elicited by glutamate (GLU). The attenuation of GLU-elicited depressor responses was time-dependent for MAP changes and time and concentration-dependent for HR changes (p < 0.05). Insulin-like growth factor-1 microinjection into the NTS also attenuated GLU-elicited decreases in MAP (p < 0.05) but not HR. The effect of insulin on GLU-elicited responses was inhibited after peripheral adrenergic blockade by nadolol (1.0 mg/kg i.v.) but not after cholinergic blockade by methyl-atropine (2.0 mg/kg i.v.). These results demonstrate that insu...Continue Reading

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Citations

Feb 9, 2011·The Journal of Physiology·Priscila A CassagliaVirginia L Brooks
Jun 6, 2012·Behavioural Brain Research·Robert M CampJohn D Johnson
Mar 4, 2011·Current Opinion in Pharmacology·Debra I DizE Ann Tallant
Jun 29, 2014·Experimental Physiology·Mona A AbrahamTony K T Lam
Apr 18, 2008·Canadian Journal of Physiology and Pharmacology·Kenneth M MaddenGraydon S Meneilly
Feb 17, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Daisy L DaubertVirginia L Brooks
Nov 2, 2018·Current Hypertension Reviews·Beihua ZhongDonna H Wang
Jan 31, 2015·Journal of Cardiovascular Pharmacology·Chris L SchaichDebra I Diz
Nov 14, 1998·The American Journal of Physiology·Z K KrowickiP J Hornby
Feb 18, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Kenneth M MaddenGraydon S Meneilly

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