PMID: 8584221Oct 13, 1995Paper

Insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures

Neuroscience Letters
M TanakaT Marunouchi

Abstract

Using the slice culture system of 9-day-old rat cerebellum, effects of insulin on cell death of developing granule neurons were examined. Apoptotic cells were observed after 3 days culture by the in situ nick end labeling technique. Insulin deprivation induced apoptosis of granule neurons largely in the external granular layer, but scarcely in the internal granular layer. Proliferation of external granular layer neurons during the early culture period was not affected significantly by the insulin deprivation. These results suggest that insulin may prevent apoptosis of premigratory granule neurons during the development of the cerebellar cortex.

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Citations

Apr 14, 2010·Archives of Neurology·Jeffrey M BurnsWilliam M Brooks
Sep 8, 2012·Molecular Neurobiology·Rasoul GhasemiAbolhassan Ahmadiani
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Aug 19, 2006·Progress in Neurobiology·Lars P van der HeideMarten P Smidt

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis