PMID: 8584010Oct 4, 1995Paper

Insulin receptor binding from mid-term and full-term placentas of patients with gestational diabetes mellitus and normal pregnant women

Molecular and Cellular Biochemistry
O S al-Attas

Abstract

Insulin receptor binding was examined in the microvillous membranes of mid-term (20-22 weeks of gestation, MT) and full-term (FT) placentas from patients with gestational diabetes mellitus (GDM) and in normal pregnant control (N). Mid-term placentas were obtained from patients who have had spontaneous abortion. The maximum per cent specific binding (%SB) in MT placenta for GDM was significantly lower (4.8%) compared with the FT placenta (22%, p < 0.001), while in the N group the maximum per cent specific binding for MT placenta was 14.1% compared with 26% for the FT placenta (p < 0.001). Binding data from FT placenta of well-controlled GDM patients were similar with the FT placenta from N group (22% SB for GDM VS 26% SB for N). Even as there were similarities in the binding characteristics of FT placentas from both groups the placental membrane protein content in the GDM group was lower by 50% compared with the N control (2.5 +/- 0.11 VS 4.8 +/- 0.15 mg protein/g placenta respectively, p < 0.001) suggesting that in the GDM group achieving a tight glycemic control could improve receptor affinities. Data from the competitive binding assay of GDM patients showed that the insulin necessary to achieve 50% inhibition (ID50) was signi...Continue Reading

References

Feb 1, 1979·Diabetologia·S Durán-GarcíaA M Cabello
Jan 1, 1990·Gynecologic and Obstetric Investigation·D M NelsonE M Curran
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·O S al-Attas
Feb 1, 1986·The Australian & New Zealand Journal of Obstetrics & Gynaecology·D A Abell
Feb 1, 1986·The Australian & New Zealand Journal of Obstetrics & Gynaecology·J N Oats, N A Beischer

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Citations

Feb 21, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·Y YiT Costacou

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