PMID: 18406819Apr 15, 2008Paper

Insulin receptor what role in breast cancer?

Trends in Endocrinology and Metabolism : TEM
V PapaA Belfiore

Abstract

It is commonly believed that the insulin receptor mainly mediates the metabolic effects of insulin, whereas the closely related IGF-I receptor is considered a major factor for the regulation of cell proliferation. Experimental and epidemiological evidence indicates, however, that insulin and insulin receptors may play an important role in breast cancer. This article reviews evidence indicating that (a) insulin receptors are overexpressed in human breast cancer, (b) insulin stimulates growth in breast cancer cells, (c) cells transfected with human insulin receptor may acquire a ligand-dependent transformed phenotype, and (d) breast cancer is associated with insulin resistance and hyperinsulinemia. These findings may open new possibilities in breast cancer prevention, prognosis assessment, and therapy. (Trends Endocrinol Metab 1997; 8:306-312). (c) 1997, Elsevier Science Inc.

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Citations

Mar 18, 2011·International Journal of Cancer. Journal International Du Cancer·Sabina SieriVittorio Krogh
Apr 10, 2009·Molecular Systems Biology·Nikolay BorisovBoris N Kholodenko
Nov 16, 2011·Medical Oncology·Muhammet Ali KaplanAbdurrahman Isikdogan
Jul 9, 2013·Pathology Oncology Research : POR·Swaroopa YerrabothalaVincent A Debari
May 22, 2013·Journal of Molecular Endocrinology·Chanchal Gupta, Kulbhushan Tikoo
Sep 20, 2015·Hormones & Cancer·Jun WangSusan E Hankinson
May 25, 2011·Endocrine-related Cancer·Antonino Belfiore, Roberta Malaguarnera
Oct 8, 2011·Health Care for Women International·Lilit KhachatryanSarah Kagan
Dec 21, 2016·Cancer Causes & Control : CCC·Marjory CharlotJulie R Palmer
Dec 26, 2001·Brain Research. Molecular Brain Research·P OstlundK Bedecs
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B A Stoll

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