Insulin-related growth factor binding protein-1 levels in ovum donation pregnancies

European Journal of Obstetrics, Gynecology, and Reproductive Biology
A A BrooksH I Abdalla

Abstract

The finding that endometrial maturation may be delayed following hormone replacement therapy has suggested that a generalised endometrial dysfunction may exist in ovum recipients. In order to investigate this suggestion further, circulating levels of IGFBP-1 were measured in samples taken throughout pregnancies conceived either spontaneously or following ovum donation. When analysed at two-weekly intervals, the serum levels of IGFBP-1 in ovum donation pregnancies failed to show the expected peak towards the end of the first trimester and were significantly reduced at week ten (U = 364.5, p = 0.0002) and twelve (U = 138.0, p = 0.0047). For the remainder of pregnancy, circulating IGFBP-1 levels were similar in both groups. The birth weight of children born to the ovum donation group was not significantly different from a normal control group, suggesting that circulating levels of IGFBP-1 in early pregnancy do not reflect local function and that IGFBP-1 does not have an essential function (in relation to birth weight) in early pregnancy.

References

Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·F PekonenE M Rutanen
Jan 1, 1987·Journal of Steroid Biochemistry·E M RutanenM L Huhtala
Sep 1, 1986·The Journal of Clinical Endocrinology and Metabolism·E M RutanenJ G Grudzinskas
Nov 1, 1985·British Journal of Obstetrics and Gynaecology·R J HowellT Chard
Feb 1, 1980·British Journal of Obstetrics and Gynaecology·D G Altman, E C Coles

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