PMID: 7012840Dec 1, 1980Paper

Insulin release, insulin sensitivity, and glucose intolerance

Proceedings of the National Academy of Sciences of the United States of America
S EfendićR Luft

Abstract

Groups of subjects with different degrees of glucose intolerance were examined in order to determine, first, the capacity of the beta cells to release insulin upon glucose stimulation and, second, sensitivity to insulin. The groups were selected on the basis of fasting blood glucose value and tolerances to oral and intravenous glucose administration. The body weights, ages, and sexes of the subjects were well matched with those of control subjects with normal tolerances to oral and intravenous glucose administration. Computer analysis of the glucose and insulin curves during a standardized glucose infusion test made possible the measurement of the initiatory (parameters KI and IP) and potentiatory (parameter KP) effects of glucose on insulin release and of the sensitivity to endogenous insulin (parameter KG). In subjects with impaired oral but normal intravenous glucose tolerance tests, KG was decreased, KP was increased, and KI and IP were normal. However, in these subjects, KI and IP were considerably lower than in a matched group of control subjects with the same decrease in KG but with normal oral and intravenous glucose tolerance tets. In subjects in which both oral and intravenous glucose tolerance tests were impaired and...Continue Reading

References

Jul 1, 1979·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R Luft, S Efendić
Jan 1, 1976·The American Journal of Medicine·G M ReavenJ M Olefsky
Aug 1, 1974·European Journal of Clinical Investigation·E CerasiM Rudemo
Oct 1, 1968·Acta Endocrinologica·R LuftB Andersson
Oct 8, 1965·Annals of the New York Academy of Sciences·R S YalowS A Berson
Dec 1, 1967·Acta Endocrinologica·R LuftC A Hamberger
Jul 1, 1957·Acta Endocrinologica·D IKKOS, R LUFT
Jul 1, 1963·The Biochemical Journal·C N HALES, P J RANDLE

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Citations

May 1, 1988·Baillière's Clinical Endocrinology and Metabolism·J E Gerich
May 31, 2001·European Journal of Clinical Investigation·A CrettiR C Bonadonna
Jun 16, 2010·Proceedings of the National Academy of Sciences of the United States of America·Daniel H JanzenJohn M Burns
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A WajngotS Efendić
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S EfendićM Vranić
Mar 1, 1991·Journal of Internal Medicine·T KjellströmF Lindgärde
Aug 1, 1993·Journal of Internal Medicine·S Efendic, C G Ostenson
Jan 1, 1986·British Heart Journal·A HamstenL Mettinger
May 1, 1987·The Journal of Clinical Investigation·L RossettiR A DeFronzo
Feb 1, 1994·Metabolism: Clinical and Experimental·T AhmadR Taylor
Sep 1, 1985·Metabolism: Clinical and Experimental·S BevilacquaR A DeFronzo
Jan 17, 1983·The American Journal of Medicine·R A DeFronzoV Koivisto
Jan 1, 1986·Diabetes/metabolism Reviews·S S Fajans
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·J P WangJ T Cheng
Nov 1, 1986·The American Journal of Physiology·S KarlanderS Efendić

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