PMID: 36543Apr 1, 1979

Insulin release: the fuel hypothesis

Metabolism: Clinical and Experimental
W J MalaisseJohn C Hutton


The immediate and direct regulation of insulin release by circulating nutrients, especially glucose, is thought to be mediated in the pancreatic B-cell by a sequence of metabolic, ionic, and motile events. On the basis of previous work, it is assumed that the process by which glucose is recognized as an insulinotropic agent entirely depends on the metabolic changes evoked by the sugar in the islet cells. Several factors are considered as possible candidates for the coupling between these metabolic changes and subsequent ionic events such as altered phosphate, chloride, sodium, potassium, and calcium handling. It is acknowledged that changes in the concentrations of glycolytic intermediates and cyclic nucleotides (adenosine- or guanosine-3', 5'-cyclic monophosphate), or both, could play a modulatory role upon stimulated insulin release. However, the initiation of insulin release seems to depend on the generation of two essential coupling factors: H+ and reduced pyridine nucleotides. The changes in H+ fluxes may account for the glucose-induced decrease in K+ and Ca2+ fractional outflow rate, all three parameters displaying hyperbolic-like dose-response curves with half-maximal values at noninsulinotropic glucose concentrations. T...Continue Reading


Apr 1, 1977·Diabetologia·A SenerW J Malaisse
May 1, 1977·Diabetologia·W Kemmler, G Löffler
Aug 15, 1977·Experientia·W J MalaisseG Somers
Jan 1, 1977·Biochemical Society Transactions·W J Malaisse
Nov 1, 1977·FEBS Letters·A C BoscheroW J Malaisse
Jan 18, 1978·The Journal of Membrane Biology·W J MalaisseG Somers
Apr 1, 1978·Diabetes·B J FrankelG M Grodsky
Mar 20, 1978·Pflügers Archiv : European journal of physiology·W J MalaisseJohn C Hutton
Jul 18, 1978·Pflügers Archiv : European journal of physiology·S KawazuW J Malaisse
Apr 28, 1978·Annals of the New York Academy of Sciences·W J MalaisseE Rojas
Jan 1, 1979·Endocrinology·G SomersW J Malaisse
Jan 1, 1976·The Journal of Physiology·B HellmanI B Täljedal
Sep 1, 1976·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M PierceN Freinkel
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Sep 3, 1976·Pflügers Archiv : European journal of physiology·G SomersW J Malaisse
Feb 1, 1975·Acta Physiologica Scandinavica·E Gylfe, B Hellman
Jun 30, 1975·Annals of the New York Academy of Sciences·W J MalaisseL Orci
Feb 1, 1973·The Biochemical Journal·S J AshcroftP J Randle
Nov 1, 1967·The Journal of Clinical Investigation·W J MalaisseD Mayhew
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Jul 6, 1971·Biochimica Et Biophysica Acta·B HellmanI B Täljedal


Dec 16, 1980·Molecular and Cellular Biochemistry·A Sener, W J Malaisse
Aug 1, 1995·Diabetologia·W S Zawalich, G G Kelley
Dec 1, 1987·Experientia·V Leclercq-MeyerW J Malaisse
Jan 15, 1988·Experientia·W R CarperD B Coffin
Oct 15, 1984·Experientia·A Sener, W J Malaisse
Oct 15, 1984·Experientia·L BestW J Malaisse
Jul 1, 1981·Molecular and Cellular Biochemistry·W J MalaisseF Malaisse-Lagae
Apr 1, 2006·Diabetologia·N E SimpsonI Constantinidis
Nov 15, 2012·Pflügers Archiv : European journal of physiology·Andrei I TarasovGuy A Rutter
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Mar 1, 1987·General and Comparative Endocrinology·P Ronner, A Scarpa
Jan 1, 1988·The International Journal of Biochemistry·A SenerW J Malaisse
May 1, 1992·The International Journal of Biochemistry·W J Malaisse
Apr 28, 1980·Life Sciences·W J MalaisseA Sener
Nov 10, 1986·Life Sciences·M D MeglassonFranz M Matschinsky
Jan 1, 1992·Life Sciences·P LebrunA Herchuelz
Jan 1, 1986·Advances in Enzyme Regulation·W J Malaisse
Jun 15, 1989·Biochimica Et Biophysica Acta·J F GeschwindM Prentki
Jun 10, 1992·Biochimica Et Biophysica Acta·R J KonradB A Wolf
Jan 1, 1981·Peptides·J C BrownR A Pederson
Oct 1, 1983·Molecular and Cellular Endocrinology·L Best, W J Malaisse
Aug 1, 1987·Molecular and Cellular Endocrinology·M T YilmazW J Malaisse
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Oct 1, 1996·The International Journal of Biochemistry & Cell Biology·C VanhoutteW J Malaisse
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May 27, 2005·Seminars in Fetal & Neonatal Medicine·Khalid Hussain
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A SenerW J Malaisse
Jan 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S A Metz
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·Frans SchuitD Pipeleers
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Patrick E MacDonaldPatrik Rorsman
Dec 30, 1987·European Journal of Biochemistry·A SenerW J Malaisse
Jul 5, 1990·European Journal of Biochemistry·W J MalaisseE Van Schaftingen
Apr 1, 1993·European Journal of Biochemistry·A C ElliottL Best
Jan 1, 1986·Annals of the New York Academy of Sciences·P Ronner
Feb 1, 1990·The Journal of Clinical Investigation·B A WolfJ Turk
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Mar 6, 1976·Lancet·R E Warren, S O Roberts
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Sep 11, 1989·FEBS Letters·W J MalaisseE Van Schaftingen
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