Insulin resistance and abnormal ovarian responses to human chorionic gonadotropin in chronically anovulatory women

American Journal of Obstetrics and Gynecology
J KustinR W Rebar

Abstract

We studied the interrelationships between insulin resistance, obesity, and abnormal ovarian androgen secretion in chronically anovulatory women with clinical or biochemical evidence of hyperandrogenism. Four groups of six subjects each were studied: (1) normal weight (within 10% ideal body weight) anovulatory, (2) obese (greater than 120% ideal body weight) anovulatory, (3) normal weight eumenorrheic, and (4) obese eumenorrheic. After dexamethasone suppression, human chorionic gonadotropin (2000 IU/1.5m2 body surface area intramuscularly) was administered to each subject. Serum testosterone levels were subsequently determined hourly for 17 hours. On a separate occasion, an oral glucose tolerance test was administered to five subjects from each group. Serum glucose and immunoreactive insulin levels were determined before and after the ingestion of a standard 100 gm glucose load. As a group, the anovulatory women had higher (p less than 0.05) basal testosterone levels (1005 +/- 97 pg/ml) than did the ovulatory women (241 +/- 21 pg/ml) (values +/- SE). Obesity per se was not associated with increased basal testosterone levels. Testosterone levels rose in response to human chorionic gonadotropin (p less than 0.005) only in obese an...Continue Reading

References

Aug 1, 1975·Endocrinology·J P LouvetG T Ross
Mar 18, 1976·The New England Journal of Medicine·M A KirschnerD Jespersen
Sep 1, 1984·Obstetrics and Gynecology·R L BarbieriK J Ryan
Jun 1, 1984·The Journal of Clinical Endocrinology and Metabolism·Y W ZhangR W Rebar
Apr 1, 1980·Clinical Endocrinology·P G KopelmanS L Jeffcoate
Jan 1, 1980·The Journal of Clinical Endocrinology and Metabolism·G A BurghenA E Kitabchi

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Citations

Feb 1, 1997·Journal of Assisted Reproduction and Genetics·H H HatasakaR S Jeyendran
Dec 19, 2001·Environmental Health Perspectives·V PerskyUNKNOWN Great Lakes Consortium
Feb 15, 2002·Human Fertility : Journal of the British Fertility Society·Roy Taylor, Philippa J. Marsden
Sep 2, 1999·Human Reproduction·P J MarsdenR Taylor
Jan 5, 2002·The American Journal of Clinical Nutrition·Victoria W PerskySusan Potter

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