Insulin resistance and breast cancer incidence and mortality in postmenopausal women in the Women's Health Initiative.

Cancer
Kathy PanRebecca A Nelson

Abstract

Insulin resistance is associated with higher all-cause and cancer-specific mortality in postmenopausal women. However, to the authors' knowledge, information regarding insulin resistance and breast cancer mortality risk is limited. Therefore, the authors examined associations between insulin resistance and breast cancer incidence and mortality in a subsample of Women's Health Initiative participants. A total of 22,837 postmenopausal women with fasting baseline glucose and insulin levels were followed for incident breast cancer and breast cancer mortality. Breast cancers were verified by medical record review and serial National Death Index linkage-enhanced mortality findings. Insulin resistance was estimated using the homeostatic model assessment of insulin resistance (HOMA-IR). Multivariable Cox proportional hazards models were used to compute hazard ratios (HRs) with 95% confidence intervals (95% CIs) for quartile comparisons. Outcomes included breast cancer incidence, deaths from breast cancer, and deaths after breast cancer (breast cancer followed by death from any cause). During a median of 19.8 years of follow-up of 1328 breast cancer cases, there were 512 deaths reported, 151 of which were from breast cancer. Breast canc...Continue Reading

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Citations

Mar 16, 2021·BMC Medicine·Giuseppe PennoUNKNOWN Renal Insufficiency And Cardiovascular Events (RIACE) Study Group
Jan 28, 2022·Scientific Reports·Pierre R BushelBenedict Anchang
Jan 21, 2022·International Journal of Cancer. Journal International Du Cancer·Anthony J SwerdlowMichael E Jones

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