Insulin resistance and cardiometabolic risk factors in obese children and adolescents: a hierarchical approach

Journal of Pediatric Endocrinology & Metabolism : JPEM
Irine-Ikbale SakouArtemis Tsitsika

Abstract

This study aims to globally assess the network of insulin resistance (IR)-related factors in a sample of overweight and obese Greek youths. A total of 185 subjects were examined, and IR was quantified by homeostasis model assessment (HOMA-IR). Multivariate hierarchical approach was performed, and five distinct levels were recognized, namely, immutable demographic features and early life parameters, current anthropometric measures, IR, unfavorable clinical conditions, and social parameters. Two analyses were performed based on HOMA-IR cut-off values (3.16 and, as an alternative, 3.99). Obesity was associated with IR (adjusted OR=3.19, 95% CI: 1.12-9.09). IR steadily predicted low HDL (adjusted OR=5.75, 95% CI: 1.58-20.87), hypertriglyceridemia (adjusted OR=10.28, 95% CI: 1.18-89.55), and systolic hypertension. At the alternative analysis, IR was also associated with older age, older age at menarche, hyperuricemia, and low school grades. Emerging on the grounds of obesity, IR confers risks for dyslipidemia and hypertension at a relatively early age. Along with weight loss, interventions targeted at IR are required to prevent cardiometabolic risk in adolescence.

References

Oct 16, 2002·Current Cardiology Reports·Giacomo Ruotolo, Barbara V Howard
Nov 1, 1961·The Journal of Clinical Endocrinology and Metabolism·D FERRIMAN, J D GALLWEY
Feb 27, 2004·The New England Journal of Medicine·William H Dietz
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Svetlana Ten, Noel Maclaren
Aug 3, 2004·Pediatrics·UNKNOWN National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
Feb 25, 2005·The Journal of Clinical Endocrinology and Metabolism·Karen E RemsbergRoger M Siervogel
Apr 19, 2005·BMJ : British Medical Journal·Hans WahrenbergPeter Arner
Apr 21, 2005·The Journal of Clinical Endocrinology and Metabolism·Sarah EhtishamTimothy Barrett
Dec 15, 2006·Psychosomatic Medicine·Elizabeth GoodmanLawrence M Dolan
Jan 11, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Brandon M Nathan, Antoinette Moran
Jul 4, 2008·Pediatrics·Stephen R DanielsUNKNOWN Committee on Nutrition
Dec 17, 2008·International Journal of Pediatric Obesity : IJPO : an Official Journal of the International Association for the Study of Obesity·Szilvia BokorDénes Molnár
Jul 22, 2009·Journal of Pediatric Endocrinology & Metabolism : JPEM·Maria L RoditisGerasimos E Krassas
Dec 26, 2009·European Journal of Public Health·Stavroula A PapadodimaChara A Spiliopoulou
Sep 11, 2010·The Journal of Clinical Endocrinology and Metabolism·Claire Levy-MarchalUNKNOWN Insulin Resistance in Children Consensus Conference Group
Dec 14, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S CnattingiusF Granath
Feb 22, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·D KalogeromitrosT Psaltopoulou
May 29, 2012·Nursing & Health Sciences·Eleni JelastopuluDespina Sapountzi-Krepia
Feb 1, 2013·Nutrition Journal·Anapaula Cb RizzoJosé E Corrente
Apr 5, 2013·American Journal of Epidemiology·Sarah Dee GeigerAnoop Shankar
Jul 3, 2013·Stress and Health : Journal of the International Society for the Investigation of Stress·Shana M Wilson, Amy F Sato
Aug 21, 2013·Metabolism: Clinical and Experimental·Charles J GlueckJessica G Woo
Mar 19, 2014·Pediatrics·Francisco B OrtegaUNKNOWN HELENA project group

❮ Previous
Next ❯

Citations

Sep 10, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Emily Hill GusemanJoey C Eisenmann
Sep 1, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·João Carlos LocateliNelson Nardo Junior
Apr 19, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Lingli WangXiaowei Zhao
Jun 14, 2019·Journal of Nutrition and Metabolism·Masaru Kubota
Jan 14, 2016·Internal and Emergency Medicine·Maria Felicia FaienzaPiero Portincasa
Aug 9, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Vasiliki KaravaNikoleta Printza
Jan 22, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Pei-Wen WuChien-Hung Lee
Dec 18, 2020·Frontiers in Pediatrics·Valeria CalcaterraMaria Antonietta Avanzini
Feb 20, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Fen LiMin Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.