Insulin resistance and cardiovascular disease: the role of PPARgamma activators beyond their anti-diabetic action

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Daniel Walcher, Nikolaus Marx

Abstract

Over the past few years it has been recognised that insulin resistance (IR) is an independent risk factor for major cardiovascular events. In addition, IR is associated with other factors such as hypertension, dyslipidaemia and endothelial dysfunction, and this cluster of metabolic disorders contributes to the cardiovascular risk of patients with IR. Given the increasing number of patients with IR, the modulation of their cardiovascular risk is a major task in diabetology and vascular medicine. This review will focus on the role of IR as a cardiovascular risk factor and on the potential of activators of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) to modulate these risk factors associated with IR.

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Citations

Mar 29, 2008·Metabolic Syndrome and Related Disorders·David Virsaladze
Jul 28, 2009·Journal of Neuroinflammation·Sha-Ron PierreMaria E Figueiredo-Pereira
Feb 5, 2010·Journal of Neuroinflammation·Lawrence L HorstmanAlireza Minagar
Dec 15, 2010·PloS One·Carlos RiverosUNKNOWN ANZgene Multiple Sclerosis Genetics Consortium
Jun 17, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Takayuki MatsumotoKatsuo Kamata
Feb 22, 2008·PPAR Research·Sheng Zhong DuanRichard M Mortensen
Nov 29, 2012·British Journal of Pharmacology·Fergus P McCarthySarah K Walsh
Jun 27, 2009·Journal of Cellular and Molecular Medicine·Martin SteinmetzSven Wassmann
Aug 30, 2008·Menopause : the Journal of the North American Menopause Society·Monika Mueller, Alois Jungbauer

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