Insulin resistance and cardiovascular complications in patients with essential hypertension

American Journal of Hypertension
K KamideToshio Ogihara

Abstract

Hyperinsulinemia or insulin resistance is suggested to play a role in the pathogenesis of hypertension and its target organ diseases. We designed this study to evaluate the role of insulin resistance in cardiac function, cardiac hypertrophy, wall thickness of the common carotid artery, and endothelial function of the brachial artery in essential hypertensive patients without diabetes mellitus. Insulin resistance was evaluated by the constant glucose infusion rate (M value) during the euglycemic-hyperinsulinemic glucose clamp test. In correlation analysis for several indices of glucose metabolism, only M value correlated with left ventricular mass index (LVMI), ratio of peak velocity during atrial contraction to that during early left ventricular filling phase (E/A ratio) and intima-media complex (IMC). In stepwise regression analysis of various risk factors for cardiovascular diseases, only M value and age were dependent factors for LVMI, E/A ratio, and IMC. No indices of glucose metabolism or risk factors for cardiovascular diseases correlated with endothelium-dependent and -independent vasodilation. These results suggest that insulin resistance, but not glucose intolerance and hyperinsulinemia, partly accelerates cardiovascul...Continue Reading

Citations

May 25, 2005·Journal of Internal Medicine·G MulèG Cerasola
Mar 9, 2006·The Journal of Clinical Hypertension·Giuseppe Mulè, Giovanni Cerasola
Feb 13, 2001·Endocrine Reviews·J Calles-Escandon, M Cipolla
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Junko MiyazatoYuhei Kawano
Nov 7, 2002·Journal of Human Hypertension·L A FerraraA Celentano
May 17, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Toshio IkedaRie Furutera
Mar 24, 2004·Current Diabetes Reports·Hiromi Rakugi, Toshio Ogihara
Jan 14, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Chinami OgataYuhei Kawano
Dec 17, 2015·American Journal of Physiology. Endocrinology and Metabolism·Stavroula BitsiVishwanie S Budhram-Mahadeo
Dec 16, 1998·The Journal of Clinical Endocrinology and Metabolism·R A PhillipsS Shimabukuro
Feb 5, 2002·American Journal of Hypertension·Kei KamideToshio Ogihara
Sep 25, 1999·Diabetes/metabolism Research and Reviews·D W LaightE E Anggård
Apr 12, 2003·Obesity Research·Gianluca IacobellisFrida Leonetti
Mar 9, 2002·Current Hypertension Reports·Hiromi RakugiToshio Ogihara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.