Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study

BMC Nephrology
Sarah J SchraubenHarold I Feldman

Abstract

Insulin resistance contributes to the metabolic syndrome, which is associated with the development of kidney disease. However, it is unclear if insulin resistance independently contributes to an increased risk of chronic kidney disease (CKD) progression or CKD complications. Additionally, predisposing factors responsible for insulin resistance in the absence of diabetes in CKD are not well described. This study aimed to describe factors associated with insulin resistance and characterize the relationship of insulin resistance to CKD progression, cardiovascular events and death among a cohort of non-diabetics with CKD. Data was utilized from Chronic Renal Insufficiency Cohort Study participants without diabetes (N = 1883). Linear regression was used to assess associations with insulin resistance, defined using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). The relationship of HOMA-IR, fasting glucose, hemoglobin A1c (HbA1c), and C-peptide with CKD progression, cardiovascular events, and all-cause mortality was examined with Cox proportional hazards models. Novel positive associations with HOMA-IR included serum albumin, uric acid, and hemoglobin A1c. After adjustment, HOMA-IR was not associated with CKD progre...Continue Reading

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Citations

Oct 24, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Neil E CaporasoBarry I Graubard
Mar 16, 2021·BMC Medicine·Giuseppe PennoUNKNOWN Renal Insufficiency And Cardiovascular Events (RIACE) Study Group
Apr 8, 2021·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Marzieh BakhshayeshkaramKamran Bagheri Lankarani

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Methods Mentioned

BETA
blood draw

Software Mentioned

SAS®

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