Insulin resistance and elevated levels of tissue plasminogen activator in first-degree relatives of South Asian patients with ischemic cerebrovascular disease

Stroke; a Journal of Cerebral Circulation
K KainP J Grant

Abstract

South Asians in the United Kingdom suffer from an increased mortality from cerebrovascular disease compared with whites. Evidence suggests that the relatives of white stroke patients are at increased risk of vascular disease. The aim of this study was to investigate atherothrombotic risk factors in the first-degree relatives of South Asian patients suffering from ischemic cerebrovascular disease and to compare them with South Asian subjects free from clinically detectable cerebrovascular disease. We compared 143 relatives of South Asians with ischemic stroke (South Asian relatives group) with 146 South Asian control subjects from West Yorkshire, UK. The ages and ethnic and sex distributions of South Asian relatives and South Asian controls were similar. There were no significant differences in body mass index, waist-hip ratio, number of current smokers, and past medical history of hypertension, diabetes mellitus, or myocardial infarction between the 2 groups. Fasting blood glucose, glycosylated hemoglobin (HbA(1c)), total cholesterol, triglycerides, and HDL cholesterol were similar in the 2 groups. Fasting insulin (South Asian relatives, 12.0; South Asian controls, 8.5 mU/L; P<0.0001) (independent of tissue plasminogen activato...Continue Reading

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Citations

Mar 20, 2014·Current Cardiology Reports·Arti Shah, Alka M Kanaya
Feb 7, 2008·International Journal of Cardiology·Konstantinos TziomalosAlexander M Seifalian
Jul 23, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·K KainP J Grant
Mar 5, 2008·Journal of Thrombosis and Haemostasis : JTH·K KainE M Scott
Sep 28, 2010·Primary Care Diabetes·Nitin GholapKamlesh Khunti
Jun 22, 2017·Metabolic Brain Disease·Xiao-Ling DengZhiyou Cai
Nov 14, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Nita G ForouhiNaveed Sattar
Jul 3, 2004·Vascular Medicine·Dorairaj Prabhakaran, Sonia S Anand

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