Insulin resistance and hyperinsulinaemia in the development and progression of cancer.

Clinical Science
Ian F Godsland

Abstract

Experimental, epidemiological and clinical evidence implicates insulin resistance and its accompanying hyperinsulinaemia in the development of cancer, but the relative importance of these disturbances in cancer remains unclear. There are, however, theoretical mechanisms by which hyperinsulinaemia could amplify such growth-promoting effects as insulin may have, as well as the growth-promoting effects of other, more potent, growth factors. Hyperinsulinaemia may also induce other changes, particularly in the IGF (insulin-like growth factor) system, that could promote cell proliferation and survival. Several factors can independently modify both cancer risk and insulin resistance, including subclinical inflammation and obesity. The possibility that some of the effects of hyperinsulinaemia might then augment pro-carcinogenic changes associated with disturbances in these factors emphasizes how, rather than being a single causative factor, insulin resistance may be most usefully viewed as one strand in a network of interacting disturbances that promote the development and progression of cancer.

References

Oct 21, 1992·International Journal of Cancer. Journal International Du Cancer·P F BruningW J Nooijen
Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·D K Snyder, D R Clemmons
Oct 11, 1991·The Journal of Clinical Endocrinology and Metabolism·D R ClemmonsW H Busby
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·M PugeatJ Tourniaire
Nov 1, 1990·The Journal of Clinical Investigation·V PapaR Vigneri
Sep 1, 1988·The Journal of Clinical Endocrinology and Metabolism·S R PlymateK E Friedl
May 31, 1969·Lancet·R W Stout, J Vallance-Owen
Aug 1, 1970·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J C Heuson, N Legros
Feb 1, 1967·Experimental Cell Research·J C HeusonR Heimann
May 1, 1995·The Journal of Clinical Investigation·G S HotamisligilB M Spiegelman
Jan 1, 1993·Breast Cancer Research and Treatment·L FrittittaV Trischitta
Apr 30, 1996·Annals of the New York Academy of Sciences·A BelfioreR Vigneri
Jul 1, 1996·British Journal of Obstetrics and Gynaecology·H S WangY K Soong
Mar 1, 1996·Cancer Causes & Control : CCC·E GiovannucciW C Willett
Nov 1, 1996·The Journal of Biological Chemistry·M L Goalstone, B Draznin
May 1, 1997·Endocrinology·J W LeitnerB Draznin
Sep 18, 1997·American Journal of Epidemiology·R TroisiL A Brinton
Nov 5, 1997·Biochemical and Biophysical Research Communications·M GoalstoneB Draznin
Mar 13, 1998·Breast Cancer Research and Treatment·M E Del GiudiceP J Goodwin
Jun 4, 1998·International Journal of Cancer. Journal International Du Cancer·R KaaksD E Grobbee
Jun 20, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·F LeyvaJ C Stevenson
Jun 24, 1998·Journal of the National Cancer Institute·A WolkD Trichopoulos
Aug 6, 1998·Cellular Signalling·M L Goalstone, B Draznin

❮ Previous
Next ❯

Citations

Mar 31, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Paweł Piątkiewicz, Anna Czech
Sep 28, 2012·Cancer Causes & Control : CCC·Zhihong GongPaige M Bracci
Dec 11, 2013·Journal of Pain and Symptom Management·Younak ChoiYung-Jue Bang
Jul 31, 2013·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Anita GąsiorowskaEwa Małecka-Panas
Dec 17, 2011·Nutrition and Cancer·Ajit Vikram, Gopabandhu Jena
Jan 6, 2011·Genetic Testing and Molecular Biomarkers·Andrea SaracevicAna-Maria Simundic
Nov 19, 2013·PloS One·Mélanie DeschasauxMathilde Touvier
Oct 4, 2012·Endocrine-related Cancer·Christine M FriedenreichLinda S Cook
Dec 11, 2013·Nature Reviews. Endocrinology·Geltrude Mingrone, Lidia Castagneto-Gissey
Dec 5, 2012·ISRN Endocrinology·Edoardo Mannucci
Sep 25, 2014·BioMed Research International·Yushan ChengZhenyu Zhang
Oct 2, 2012·Scandinavian Journal of Clinical and Laboratory Investigation·Hala O El-MesallamyAlaliaa M Sallam
Feb 7, 2014·Cancer Investigation·Erin A BishopDoris Mangiaracina Benbrook
Sep 12, 2015·International Journal of Cancer. Journal International Du Cancer·Qi ChenJia He
Feb 4, 2016·Journal of the National Cancer Institute·Simron SinghLorraine Lipscombe
Apr 10, 2013·Annales d'endocrinologie·Emmanuel Beck, André J Scheen
May 15, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·S A D BejaimalL L Lipscombe
Oct 3, 2013·Journal of Molecular Signaling·Erik D HedrickSanjib Chowdhury
Jul 29, 2011·Annals of the New York Academy of Sciences·Alison E HarveyStephen D Hursting
Apr 19, 2013·British Journal of Haematology·Maarten ArendsCarla E M Hollak
Jan 4, 2012·International Journal of Cancer. Journal International Du Cancer·Julie K BassettGraham G Giles
Sep 14, 2011·International Journal of Cancer. Journal International Du Cancer·Jin Ha LeeWon Ho Kim
Mar 5, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·W ChanL L Lipscombe
May 15, 2013·Diabetes, Obesity & Metabolism·S K GargR Selagamsetty
Jul 4, 2012·International Journal of Cardiology·Xavier PalomerManuel Vázquez-Carrera
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Patrizia FerroniMario Roselli
Mar 28, 2012·Gynecologic Oncology·Nan MuFengxia Xue
Mar 25, 2015·Nature Reviews. Endocrinology·Xilin YangJuliana C N Chan
Dec 7, 2010·Biochimica Et Biophysica Acta·Bin BaoFazlul H Sarkar
Mar 18, 2015·Breast Cancer Research and Treatment·Lorraine L LipscombeLawrence Paszat
Nov 27, 2014·Frontiers in Physiology·Jun GongStephen J Pandol
Jul 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mathilde JalvingElisabeth G E de Vries
Mar 8, 2017·International Journal of Cancer. Journal International Du Cancer·NaNa KeumKana Wu
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jiachen ZhengYang Xi
Jan 21, 2018·Diabetes Care·Iliana C LegaLorraine L Lipscombe

❮ Previous
Next ❯

Methods Mentioned

BETA
nucleotide-exchange
GTPase
GTPases

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Marc J GunterHoward D Strickler
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Dorthe JohansenJonas Manjer
The Journal of Clinical Investigation
B B Kahn, J S Flier
© 2022 Meta ULC. All rights reserved