Insulin resistance and pancreatic beta-cell function in patients with hypertensive kidney disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Masao KanauchiYoshihiko Saito

Abstract

Insulin resistance and hyperinsulinaemia have been reported among patients with chronic renal failure. However, little is known concerning insulin sensitivity among patients with hypertensive kidney disease (HKD), especially in those with moderate or severe renal dysfunction. We examined and compared 30 patients with HKD, 30 normotensive patients with chronic kidney disease (CKD-NT), 30 normal controls and 30 patients with hypertension and normal renal function (HTN). Moderate and severe renal dysfunction were defined according to the K/DOQI definitions (estimated glomerular filtration rates between 15 and 59 ml/min per 1.73 m(2)). The homeostasis model assessment of insulin resistance (HOMA-R) and three surrogate indexes based on 75 g oral glucose tolerance test results were used to determine insulin sensitivity. A trend to higher HOMA-R values in the HTN and HKD groups than in the other groups was noted, but the difference was not statistically significant. The insulin sensitivity index (ISI) proposed by Stumvoll et al. was significantly lower in the HTN, HKD and CKD-NT groups than in controls and was significantly lower in HKD than in the HTN and CKD-NT groups. The insulin sensitivity index proposed by Gutt et al. was signif...Continue Reading

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Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Vincent Rigalleau, Henri Gin
Aug 13, 2008·Current Opinion in Nephrology and Hypertension·Pantelis A Sarafidis
Aug 7, 2007·Journal of the Cardiometabolic Syndrome·Panteleimon A SarafidisGeorge L Bakris
Aug 27, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Roza Czabak-GarbaczBarbara Obermayer-Pietsch
Oct 22, 2016·American Journal of Physiology. Renal Physiology·Belinda SpotoCarmine Zoccali
Apr 11, 2018·The American Journal of Clinical Nutrition·Ting-Yun LinSzu-Chun Hung

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