PMID: 18209893Jan 23, 2008Paper

Insulin resistance and secretion assessment across a range of glucose tolerance from normal individuals through diabetes

Arquivos brasileiros de endocrinologia e metabologia
Fernanda H CorrêaMarília de Brito Gomes

Abstract

Our main aim was to determine the association between clinical, demographical parameters and different insulin resistance and secretion indices in apparently healthy subjects, without previous knowledge of their own level of glucose tolerance. For that purpose, we evaluated 105 individuals from February to August 2003 by means of OGTT, aged 33.4+/-1.4 years old, 57.1% female. We allocated them in four groups: group 0 (normal): individuals with BMI < 25 Kg/m(2) and normal glucose metabolism, group 1 (obese): BMI >or= 25 Kg/m(2) and normal glucose metabolism, group 2 (IFG): impaired fasting glucose and group 3 (IGT): impaired glucose tolerance. We have found statistical difference on all variables during OGTT between all groups: fasting glucose (p < 0.05), 2-hour glucose (p < 0.05), glucose peak value (p < 0.05), glucose delta (p = 0.02), glucose incremental percentage (p = 0.047), area under curve (p < 0.05), and glucose peak time (p = 0.022). We have not found difference on any variable in insulin curves or on glucose incremental velocity. Regarding insulin secretion indices there were no statistical significance in insulinogenic or delta indices, but they became significant after being corrected by insulin resistance (p = 0.00...Continue Reading

References

Jul 1, 1997·Diabetes Care·S M HaffnerM P Stern
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Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
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Oct 16, 2004·The Journal of Clinical Endocrinology and Metabolism·Ele FerranniniRalph A DeFronzo
Apr 20, 2005·Lancet·Robert H EckelPaul Z Zimmet

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Citations

Jun 11, 2008·Obesity Surgery·Hans-Erik JohanssonArvo Haenni
Jan 11, 2012·Arquivos brasileiros de endocrinologia e metabologia·Marcio Weissheimer LauriaAdauto Versiani Ramos

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