PMID: 9169094Apr 1, 1997Paper

Insulin resistance and the transcription of the glucose-6-phosphatase gene in newborn dogs

Biochemical and Molecular Medicine
B C FengR M Kliegman

Abstract

In the present report changes in the mRNA level of glucose-6-phosphatase (G6Pase; EC 3.1.39) in newborn and adult dogs in vivo were studied to further test the hypotheses that neonatal hyperglycemia may be due to unsuppressed gluconeogenesis by insulin and that the antidiabetic role of insulin-like growth factor-1 (IGF-1) may be intact in newborn dogs who have consistently demonstrated insulin resistance. Our results were the following: (i) Both renal and hepatic G6Pase mRNA were expressed at birth and increased with time during a 24-h period of fasting after birth. (ii) The renal G6Pase mRNA levels in newborn dogs did not respond to either insulin or epinephrine. (iii) Hyperinsulinemia lowered the liver G6Pase mRNA by only 16.3% in newborn dogs, but reduced the liver G6Pase mRNA to an undetectable level in adult dogs. (iv) Hyperglycemia decreased the hepatic G6Pase mRNA by 14.3% in newborn dogs under hyperinsulinemia. (v) Infused epinephrine did not elevate the hepatic G6Pase mRNA level in newborn dogs in the presence of hyperglycemia and hyperinsulinemia. (vi) In newborn dogs, hyper-IGF-1 rapidly reduced the hepatic G6Pase mRNA level by 50%, and hypoglycemia was unable to elevate the hepatic G6Pase mRNA level under the hyper-...Continue Reading

References

Dec 1, 1975·The American Journal of Physiology·T M ChanJ H Exton
Mar 1, 1992·Diabetes Care·D K Granner, R M O'Brien
Apr 1, 1991·Diabetes·L RossettiA Giaccari
Jun 1, 1987·Metabolism: Clinical and Experimental·R M Kliegman, S Morton
Oct 1, 1983·Archives of Biochemistry and Biophysics·D SpagnoliC C Widnell
Nov 30, 1994·Biochemical and Biophysical Research Communications·Z LiuJ Y Chou
Oct 1, 1996·Biochemical and Molecular Medicine·B C FengR M Kliegman
Dec 1, 1996·Biochemical and Molecular Medicine·B FengR M Kliegman

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Citations

Jan 21, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·J Christopher Corton, Holly M Brown-Borg
Apr 1, 1997·Biochemical and Molecular Medicine·B FengR M Kliegman
Aug 1, 1997·Biochemical and Molecular Medicine·B C FengR M Kliegman

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