PMID: 15374490Jul 1, 1990Paper

Insulin resistance as cause of increased blood pressure in the elderly: effects on intracellular ion contents

Archives of Gerontology and Geriatrics
G PaolissoF D'Onofrio

Abstract

Previous reports have evidenced a strong relationship between high plasma insulin levels and blood pressure in diabetic and obese subjects but not in the elderly. During aging many patho-physiological changes in cardiovascular functions and autonomic nervous system occur, so that aging per se might be a cause of a 'physiological' increase in blood pressure. Nevertheless, an insulin resistance also develops during aging. The present study investigates the possible role of age-dependent insulin resistance in the genesis of increased blood pressure. Our data show that insulin resistance calculated by the glucose infusion rate during a euglycemic hyperinsulinemic glucose clamp procedure is significantly correlated with the insulin-mediated net decrease in erythrocyte Na+ content (r = 0.58, P < 0.05), as well as with net increase in erythrocyte K+ (r = 0.64, P < 0.05) and Mg2+ (r = 0.67, P < 0.01) content and to basal diastolic blood pressure (r = -0.63, P < 0.05). We conclude that in elderly subjects the age-related and normally occurring insulin resistance might contribute to the increase of arterial blood pressure through its effect on cell cation content.

References

Jan 1, 1987·Annals of the Academy of Medicine, Singapore·R D Kennedy
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Citations

Jan 1, 1996·Archives of Gerontology and Geriatrics·M VarricchioG Paolisso
Jul 26, 2006·Blood Pressure·Pantelis A Sarafidis, Peter M Nilsson
Jul 10, 2009·The Cochrane Database of Systematic Reviews·James M Wright, Vijaya M Musini
Apr 19, 2018·The Cochrane Database of Systematic Reviews·James M WrightRupam Gill
Sep 1, 1992·Thorax·S D Anderson, E Daviskas

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