Abstract
This study was intended to identify significant determinant factors of insulin resistance. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance (HOMA-R) and was calculated as "Fasting plasma glucose × Fasting serum insulin)/405". The target subjects were 3008 working men. The serum lipid profiles, uric acid level, insulin level, plasma glucose level, hemoglobin A1C level, and blood pressure, in addition to the waist circumference or body mass index, were also measured. A stepwise multiple regression analysis was performed using log-transformed values of HOMA-R as the dependent variable. The standardized regression coefficient for waist circumference was about six times larger than that for hemoglobin A1c (0.45 and 0.08, respectively). The standardized regression coefficients for the other factors were 0.15 for diastolic blood pressure, 0.10 for the low-density lipoprotein cholesterol level, -0.06 for age, -0.04 for habitual exercise, 0.14 for no habitual drinking, and 0.07 for no smoking. When body mass index was substituted for waist circumference, almost the same results were obtained. The adverse effects of no smoking and no habitual drinking on the HOMA-R score might be explained, at...Continue Reading
References
Jun 1, 1991·Diabetologia·E FerranniniM P Stern
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Jun 17, 2000·Diabetes Care·E BonoraM Muggeo
Mar 27, 2001·BMJ : British Medical Journal·J P DesprésD Prud'homme
Sep 13, 2002·Journal of the American College of Cardiology·Fahim AbbasiGerald M Reaven
Nov 26, 2002·American Journal of Epidemiology·David E LaaksonenTimo A Lakka
Jan 12, 2005·Diabetes, Obesity & Metabolism·H OhnishiK Shimamoto
Sep 13, 2005·Atherosclerosis·Kuo-Liong ChienYuan-Teh Lee
Mar 16, 2006·Journal of Epidemiology·Minoru SugiuraAkihiko Nagao
May 17, 2007·The Journal of Clinical Endocrinology and Metabolism·Ele FerranniniUNKNOWN RISC Investigators
May 26, 2007·Endocrine Reviews·Ranganath MuniyappaMichael J Quon
Dec 12, 2007·Diabetes Care·Yuka MatobaRyoichi Takayanagi
Jan 14, 2009·BMC Endocrine Disorders·Shinji TabataSuminori Kono
Mar 21, 2009·Lancet·UNKNOWN Prospective Studies CollaborationRichard Peto
Citations
Oct 1, 2011·Obesity Research & Clinical Practice·Hiroaki UenoMasamitsu Nakazato
May 17, 2011·Diagnostic Pathology·Wonae Lee
Mar 13, 2019·Journal of Physical Therapy Science·Yoshikazu HirasawaYutaka Seino