Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease.

Oxidative Medicine and Cellular Longevity
Lisa LongatoSuzanne M de la Monte

Abstract

Chronic alcohol-related liver disease (ALD) is mediated by insulin resistance, mitochondrial dysfunction, inflammation, oxidative stress, and DNA damage. Recent studies suggest that dysregulated lipid metabolism with accumulation of ceramides, together with ER stress potentiate hepatic insulin resistance and may cause steatohepatitis to progress. We examined the degree to which hepatic insulin resistance in advanced human ALD is correlated with ER stress, dysregulated lipid metabolism, and ceramide accumulation. We assessed the integrity of insulin signaling through the Akt pathway and measured proceramide and ER stress gene expression, ER stress signaling proteins, and ceramide profiles in liver tissue. Chronic ALD was associated with increased expression of insulin, IGF-1, and IGF-2 receptors, impaired signaling through IGF-1R and IRS1, increased expression of multiple proceramide and ER stress genes and proteins, and higher levels of the C14, C16, C18, and C20 ceramide species relative to control. In human chronic ALD, persistent hepatic insulin resistance is associated with dysregulated lipid metabolism, ceramide accumulation, and striking upregulation of multiple ER stress signaling molecules. Given the role of ceramides a...Continue Reading

References

Jun 1, 1992·Gastroenterology·M J MüllerF W Schmidt
Jul 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y T KruszynskaN McIntyre
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R TaylorK G Alberti
Feb 28, 1994·Biochemical and Biophysical Research Communications·Y Sasaki, J R Wands
Jan 12, 1999·Alcoholism, Clinical and Experimental Research·K BanerjeeS M de la Monte
Jun 1, 1997·Seminars in Cell & Developmental Biology·B LiuY A Hannun
Oct 25, 2000·Alcoholism, Clinical and Experimental Research·I V DeaciucC J McClain
Jul 20, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·E W KraegenS M Furler
Nov 28, 2001·The Journal of Biological Chemistry·Nicole A BourbonMark Kester
Jan 15, 2003·The Journal of Biological Chemistry·Jose Antonio ChavezScott A Summers
Jan 18, 2003·The Journal of Clinical Investigation·Carmen García-RuizJosé C Fernández-Checa
Apr 5, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Peter P Ruvolo
Aug 27, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jong Eun YeonSuzanne M De La Monte
Dec 20, 2003·Cell Death and Differentiation·S Oyadomari, M Mori
Dec 25, 2003·Diabetes·John M AdamsLawrence J Mandarino
Mar 12, 2004·Cancer Letters·C Patrick ReynoldsRichard N Kolesnick
Oct 16, 2004·Science·Umut OzcanGökhan S Hotamisligil
Jan 27, 2005·Science's STKE : Signal Transduction Knowledge Environment·Elina Ikonen, Saara Vainio
Jan 28, 2005·Science of Aging Knowledge Environment : SAGE KE·Mark E Obrenovich, Vincent M Monnier
Feb 12, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Farah EsfandiariCharles H Halsted
Feb 1, 2006·Progress in Lipid Research·Scott A Summers
Apr 18, 2006·Cancer Cell·Arkaitz CarracedoGuillermo Velasco
Jul 11, 2006·Methods : a Companion to Methods in Enzymology·Jacek BielawskiAlicja Bielawska
Mar 3, 2007·Journal of Leukocyte Biology·Grégory SeumoisFabrice Bureau
Mar 6, 2007·The Journal of Biological Chemistry·Laura PickersgillStephen J Yeaman
Mar 14, 2007·Archives of Ophthalmology·Xinzhi ZhangK M Venkat Narayan
Jun 15, 2007·Alcoholism, Clinical and Experimental Research·Martin J J RonisJan Calissendorff
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Puneet PuriArun J Sanyal
Nov 6, 2007·Seminars in Liver Disease·Neil KaplowitzCheng Ji
Dec 25, 2007·Advances in Chronic Kidney Disease·Leslie Spry
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
May 13, 2008·Gastroenterology·Scott L Friedman

❮ Previous
Next ❯

Citations

Feb 23, 2013·World Journal of Gastroenterology : WJG·Carmine Finelli, Giovanni Tarantino
Jan 18, 2014·Cell Death & Disease·K Wang
May 29, 2014·International Journal of Hepatology·Cheng Ji
Dec 29, 2013·Acta Neuropathologica·Suzanne M de la Monte, Jillian J Kril
Aug 22, 2015·Expert Review of Gastroenterology & Hepatology·He Joe WangMary Katherine Jung
Dec 20, 2015·Journal of Alzheimer's Disease : JAD·Chetram DeochandSuzanne M de la Monte
Jan 25, 2014·International Journal of Experimental Pathology·Ming TongSuzanne M de la Monte
Mar 22, 2016·The Journal of Physiology·Scott A Summers, Bret H Goodpaster
Sep 17, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Ming TongSuzanne M de la Monte
Sep 17, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Ming TongSuzanne M de la Monte
Apr 24, 2015·Alcoholism, Clinical and Experimental Research·Chelsea Q XuMiran Kim
Aug 29, 2013·Journal of Lipids·Raghavendra Pralhada RaoM R Jagannath
Oct 30, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Liu YangJun-Ying Zhou
Jun 20, 2013·Toxicology and Applied Pharmacology·Mohammed El Amine BenarbiaYves Malthièry
Apr 20, 2016·Expert Review of Gastroenterology & Hepatology·Fa-Ling WuMing-Hua Zheng
Aug 16, 2016·European Journal of Medicinal Chemistry·Navaneethakrishnan PolachiChangxiao Liu
Jan 13, 2018·Journal of Neural Transmission·Liubov S KalinichenkoChristian P Müller
Nov 13, 2018·Journal of Cellular Biochemistry·Marwa Mohamed AtefMarwa Nagy Emam
Sep 22, 2012·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Teresa RamirezSuzanne M de la Monte
Jan 1, 2013·Brain Sciences·Mariko Saito, Mitsuo Saito
Dec 26, 2013·American Journal of Physiology. Endocrinology and Metabolism·Piotr ZabielskiK Sreekumaran Nair
Feb 8, 2020·Journal of Lipid Research·Sookyoung Jeon, Rotonya Carr
Sep 3, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bianca WilliamsRotonya M Carr
May 14, 2020·Journal of Lipid Research·Jason CorrentiRotonya M Carr
Sep 28, 2017·Cancers·Pierluigi RamadoriYulia A Nevzorova
Dec 1, 2017·Biological & Pharmaceutical Bulletin·Ying YangYue Gao
Aug 29, 2018·Scientific Reports·Jason M CorrentiRotonya M Carr
Jun 27, 2020·World Journal of Gastroenterology : WJG·Umair KamranAndrew Holt
Jun 17, 2020·FEBS Letters·Woo-Jae Park, Joo-Won Park
Jan 27, 2015·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Valerie ZabalaSuzanne M de la Monte
Feb 2, 2013·Current Opinion in Rheumatology·Changgui LiShun-Jen Chang
Apr 5, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Tejasav S SehrawatHarmeet Malhi
Dec 23, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Yuan RuShankuan Zhu
Feb 1, 2021·Biochemical and Biophysical Research Communications·Yue XinXiwen Xiong
Dec 1, 2019·Liver Research·Ryan J Schulze, Wen-Xing Ding
Mar 18, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Fei XueJessica L Maiers

❮ Previous
Next ❯

Datasets Mentioned

BETA
GM3

Methods Mentioned

BETA
acylation
ELISAs
biopsies
biopsy
ELISA
deacylation

Software Mentioned

GraphPad Prism
Analyst
ProbeFinder

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Adrenoleukodystrophy

Adrenoleukodystrophy (ALD), the most frequent peroxisomal disorder, is an X-linked disorder caused by a defect in the metabolism of long chain fatty acids leading to demyelination, neurodegeneration, and death. Here is the latest research.

Related Papers

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Teresa RamirezSuzanne M de la Monte
International Journal of Environmental Research and Public Health
Suzanne M de la MonteJack R Wands
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Suzanne M de la MonteJack R Wands
© 2021 Meta ULC. All rights reserved