Insulin resistance does not impair response of chronic hepatitis C virus to direct-acting antivirals, and improves with the treatment

European Journal of Gastroenterology & Hepatology
Mostafa ElhelbawyImam Waked

Abstract

Insulin resistance (IR) is a common complication in chronic hepatitis C virus (HCV) patients. The impact of IR on outcome of therapy with direct antivirals has not been studied. The aim was to assess the impact of direct-acting antiviral (DAA) therapy on IR status in chronic HCV patients. A total of 511 patients [mean age: 50.7±10.4 years, 29.7% pegylated interferon and ribavirin (RBV) experienced] were enrolled. Patients with uncontrolled diabetes, decompensated liver disease, or previous nonresponse to DAAs were excluded. Homeostatic model assessment (HOMA) was calculated before and 12 weeks after treatment, and IR was defined as HOMA greater than 1.9. Patients were treated according to the treating physician's choice, and received 12 weeks of either ombitasvir/ritonavir/paritaprevir/RBV (n=28); sofosbuvir (SOF)/simeprevir (n=36); SOF/ravidasvir (n=101); SOF/pegylated interferon/RBV (n=192); or 24 weeks of SOF/RBV (n=154). Most patients received IR pretreatment (80.6%); 51.3% had fibrosis stage F4 and 24.7% had diabetes. A sustained virological response (SVR) at 12 weeks after treatment (SVR12) was achieved in 465 (91%) patients. SVR12 was achieved in 90.5% of patients with IR and in 92.9% of patients without IR (P=0.560), an...Continue Reading

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Citations

Jul 13, 2019·Tropical Doctor·Ayman Alsebaey, Mostafa Elhelbawy
Aug 9, 2019·Expert Review of Anti-infective Therapy·Ayman AlsebaeyImam Waked
Oct 10, 2019·Journal of Viral Hepatitis·Francesco Paolo RussoAndrea Mega
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Oct 8, 2020·Arquivos De Gastroenterologia·Lohanna Strauhs-NitschClaudia Alexandre Pontes Ivantes
Jun 1, 2021·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Ferdinando Carlo SassoLuca Rinaldi
Aug 28, 2021·World Journal of Gastroenterology : WJG·Tiffany KhooJohn K Olynyk

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Methods Mentioned

BETA
PCR
biopsy
pregnancy

Software Mentioned

FibroScan
SPSS Statistics

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