Insulin resistance in Alzheimer disease: Is heme oxygenase-1 an Achille's heel?

Neurobiology of Disease
Eugenio Barone, D Allan Butterfield

Abstract

Insulin resistance, clinically defined as the inability of insulin to increase glucose uptake and utilization, has been found to be associated with the progression of Alzheimer disease (AD). Indeed, postmortem AD brain shows all the signs of insulin resistance including: (i) reduced brain insulin receptor (IR) sensitivity, (ii) hypophosphorylation of the insulin receptor and downstream second messengers such as IRS-1, and (iii) attenuated insulin and insulin growth factor (IGF)-1 receptor expression. However, the exact mechanisms driving insulin resistance have not been completely elucidated. Quite recently, the levels of the peripheral inducible isoform of heme oxygenase (HO-1), a well-known protein up-regulated during cell stress response, were proposed to be among the strongest positive predictors of metabolic disease, including insulin resistance. Because our group previously reported on levels, activation state and oxidative stress-induced post-translational modifications of HO-1 in AD brain and our ongoing studies to better elucidate the role of HO-1 in insulin resistance-associated AD pathology, the aim of this review is to provide reader with a critical analysis on new aspects of the interplay between HO-1 and insulin r...Continue Reading

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J HavrankovaM Brownstein
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Jan 1, 1997·Annual Review of Pharmacology and Toxicology·M D Maines
Jan 1, 1997·Free Radical Biology & Medicine·W R Markesbery
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Aug 28, 1998·Journal of Neural Transmission·L FrölichP Riederer
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·S DoréS H Snyder
Jun 13, 2000·Alzheimer Disease and Associated Disorders·M Takahashi, S H Snyder
Jan 5, 2001·BMJ : British Medical Journal·D Josefson
Jul 20, 2001·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H E Lebovitz
Nov 28, 2001·Alzheimer Disease and Associated Disorders·L E HebertD A Evans
Dec 6, 2001·Trends in Molecular Medicine·D A ButterfieldA Castegna
Jul 12, 2002·Journal of Neural Transmission·J A MolinaY Sayed
Dec 4, 2002·Acta Neurologica Scandinavica·J A MolinaJ Arenas
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shaw-Fang YetMark A Perrella
Dec 23, 2003·The Journal of Biological Chemistry·Xuchen ZhangPatty J Lee
May 5, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H Fai PoonD Allan Butterfield
Sep 4, 2004·Antioxidants & Redox Signaling·Mahin D Maines
Sep 4, 2004·Antioxidants & Redox Signaling·Roland Stocker
Sep 4, 2004·Antioxidants & Redox Signaling·Atsushi TakedaMark A Smith
Nov 4, 2004·Biochemical and Biophysical Research Communications·Amy BishopBruce Demple
Mar 1, 2005·Trends in Endocrinology and Metabolism : TEM·Leona PlumJens C Brüning
Dec 17, 2005·Antioxidants & Redox Signaling·Mahin D Maines
Mar 4, 2006·Pharmacology & Therapeutics·Asterios S TsiftsoglouLefkothea C Papadopoulou
Jun 30, 2006·Journal of Neurochemistry·Barry Halliwell
Jul 6, 2006·The European Journal of Neuroscience·Jennifer M HorwoodSabrina Davis
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Oct 13, 2006·Antioxidants & Redox Signaling·Vittorio CalabreseD A Butterfield
Oct 19, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yong LinLinda J Noble-Haeusslein
Feb 24, 2007·Journal of the Neurological Sciences·Paula I MoreiraCatarina R Oliveira
Sep 21, 2007·Nature Reviews. Neuroscience·Vittorio CalabreseAnna Maria Giuffrida Stella

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Citations

Mar 18, 2017·Journal of Alzheimer's Disease : JAD·Gisela Esquerda-CanalsSandra Villegas
Mar 6, 2018·Journal of Alzheimer's Disease : JAD·D Allan Butterfield
Sep 3, 2016·Proteomics. Clinical Applications·D Allan Butterfield, Tanea T Reed
May 28, 2020·Journal of Clinical Medicine·Giuseppe SferrazzoIgnazio Barbagallo
Mar 23, 2018·Journal of Alzheimer's Disease : JAD·D Allan Butterfield, Debra Boyd-Kimball
Jun 20, 2019·Frontiers in Neuroscience·Paola GambaGabriella Leonarduzzi
Sep 15, 2020·Life Sciences·Vivek Kumar Sharma, Thakur Gurjeet Singh

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