Insulin resistance in chronic uremia

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
Gianfranco GuarnieriRocco Barazzoni

Abstract

Insulin resistance often characterizes chronic uremia, and is associated with enhanced morbidity and mortality, because it may contribute to protein-energy wasting (in turn, an independent predictor of reduced survival), atherosclerosis, and cardiovascular death. Causes of insulin resistance in chronic uremia are complex and multifactorial. Obesity is emerging as an independent risk factor for chronic kidney disease, and an expected rise in number of obese uremic patients because of the ongoing worldwide obesity epidemic is likely to increase the prevalence of insulin resistance in chronic uremia in the near future. Similar to the general population, reported associations between obesity and insulin resistance in chronic uremia support a role of adipose tissue and altered adipokine profiles in insulin resistance in obese chronic kidney disease patients. Hormonal imbalances, chronic acidosis, and systemic inflammation and oxidative stress are uremia-associated relevant causes of insulin resistance in nonobese individuals. A further understanding of the causes of insulin resistance in chronic uremia represents a potential important tool in the design of more effective therapeutic strategies to reduce uremia-associated morbidity a...Continue Reading

References

Mar 1, 1985·The Journal of Clinical Investigation·M AkmalR A DeFronzo
Feb 1, 1981·The Journal of Clinical Investigation·R A DeFronzoJ Wahren
Apr 6, 2001·Diabetes·M TschöpM L Heiman
Feb 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marion MorenaBernard Canaud
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Kayo ShinoharaYoshiki Nishizawa
Sep 11, 2002·Blood Purification·Béatrice Descamps-LatschaVéronique Witko-Sarsat
Feb 13, 2004·The New England Journal of Medicine·Kitt Falk PetersenGerald I Shulman
May 20, 2005·Journal of the American Society of Nephrology : JASN·Manjula KurellaGlenn M Chertow
Oct 4, 2005·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Serkan KahramanCetin Turgan
Oct 14, 2005·Kidney International·Dominic S C RajPope Moseley
Apr 28, 2006·Journal of the American Society of Nephrology : JASN·Elisabeth EjerbladOlof Nyrén
Jul 11, 2006·The Journal of Clinical Investigation·Takashi KadowakiKazuyuki Tobe
Aug 9, 2006·Seminars in Dialysis·Michel Chonchol
Sep 29, 2006·Journal of the American Society of Nephrology : JASN·Biruh T WorkenehWilliam E Mitch
Feb 22, 2007·Current Neurovascular Research·Kenneth MaieseZhao Zhong Chong
Mar 17, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rocco BarazzoniGianfranco Guarnieri
Mar 22, 2007·Journal of Lipid Research·Jaswinder K Sethi, Antonio J Vidal-Puig
Apr 13, 2007·Physiological Reviews·David B SavageGerald I Shulman
May 15, 2007·Gastroenterology·Steven E ShoelsonAfia Naaz
Jul 27, 2007·The Journal of Clinical Endocrinology and Metabolism·Rocco BarazzoniGianfranco Guarnieri
Aug 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Ihab M Wahba, Robert H Mak
Sep 15, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rocco BarazzoniGianfranco Guarnieri
Dec 12, 2007·Obesity·Rocco BarazzoniGianfranco Guarnieri
Dec 20, 2007·Current Opinion in Nephrology and Hypertension·Jonas Axelsson, Peter Stenvinkel
Dec 21, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yongzhong WeiJames R Sowers
Jan 12, 2008·The Journal of Clinical Investigation·Charlotte BonnardJennifer Rieusset
Feb 8, 2008·Journal of the American Society of Nephrology : JASN·Luis F RamosJonathan Himmelfarb

❮ Previous
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Citations

May 24, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Belinda SpotoCarmine Zoccali
Jul 23, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Stanisław NiemczykJoanna Matuszkiewicz-Rowińska
Sep 29, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kenneth MaieseYan Chen Shang
Aug 19, 2010·Oxidative Medicine and Cellular Longevity·Kenneth MaieseYan Chen Shang
Aug 8, 2014·Metabolic Syndrome and Related Disorders·Barbara Perez VogtJacqueline Teixeira Caramori
Feb 14, 2016·Nefrología : publicación oficial de la Sociedad Española Nefrologia·Guillermo De'MarzianiAlicia Elbert
Jun 4, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mario BonominiArduino Arduini
Aug 28, 2010·International Journal of Peptides·A LavianoF Rossi Fanelli
Mar 12, 2010·Journal of Clinical Pharmacology·Kenneth MaieseJinling Hou
Oct 4, 2011·Journal of Cachexia, Sarcopenia and Muscle·Mariantonietta CicoiraClaudio Ronco
Dec 15, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Roma Y GianchandaniMichael Heung
Feb 6, 2018·Eating and Weight Disorders : EWD·Rocco BarazzoniEnzo Nisoli
Oct 26, 2018·Eating and Weight Disorders : EWD·Gianluca Gortan Cappellari, Rocco Barazzoni
Sep 8, 2012·Cardiovascular Drugs and Therapy·Fa Mee DohSeung Hyeok Han
Oct 22, 2016·American Journal of Physiology. Renal Physiology·Belinda SpotoCarmine Zoccali
Aug 6, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gianluca Gortan CappellariRocco Barazzoni
Feb 25, 2011·Blood Purification·Ursula VerdallesJuan Manuel Lopez-Gomez
Feb 24, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Kinga GiersJoanna Matuszkiewicz-Rowińska
Sep 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mario BonominiArduino Arduini

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