PMID: 9535149Apr 16, 1998Paper

Insulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle

Journal of Hypertension
H LaineP Nuutila

Abstract

To determine whether insulin-stimulated blood flow in patients with mild essential hypertension is altered. Eleven untreated mildly hypertensive patients [aged 35 +/- 2 years, body mass index 25.1 +/- 0.4 kg/m2, mean arterial pressure 110 +/- 2 mmHg (means +/- SEM) and 10 matched normotensive subjects (mean arterial pressure 94 +/- 3 mmHg). Blood flow was quantitated directly in skeletal muscle both basally and during supraphysiologic hyperinsulinemia (serum insulin approximately = 450 mU/l) using radiowater ([15O]H2O) and positron emission tomography. Whole-body and femoral muscle glucose uptakes were determined using the euglycemic insulin clamp technique, [18F]-2-fluoro-2-deoxy-D-glucose and positron emission tomography. Rates of whole-body and femoral muscle glucose uptake were significantly lower in the hypertensive than in the normotensive group. Insulin increased muscle blood flow by 91% in the normotensive group, but only by 33% in the hypertensive group. The ability of insulin to stimulate blood flow in patients with mild essential hypertension is impaired.

References

Jun 1, 1992·The Journal of Clinical Investigation·P NuutilaU Wegelius
Dec 1, 1991·Metabolism: Clinical and Experimental·B CapaldoB Trimarco
Jun 1, 1991·The Journal of Clinical Investigation·E A AndersonA L Mark
Jul 5, 1990·The New England Journal of Medicine·J A PanzaS E Epstein
Oct 1, 1989·Journal of Applied Physiology·K A MossbergH Taegtmeyer
Aug 6, 1987·The New England Journal of Medicine·E FerranniniS Bevilacqua
Jan 15, 1988·Klinische Wochenschrift·H A HenrichF Bäumer
Oct 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·H IidaK Uemura
Dec 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C S Patlak, R G Blasberg
Oct 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·P RösenH Reinauer
Dec 1, 1983·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B E HowardP Freed
Oct 1, 1994·The Journal of Clinical Investigation·A NataliE Ferrannini
Dec 1, 1994·The Journal of Clinical Investigation·U ScherrerP Nicod
Apr 14, 1994·The New England Journal of Medicine·J R CockcroftJ M Ritter
May 1, 1994·The Journal of Clinical Investigation·P NuutilaU Wegelius
Jan 1, 1997·Journal of Applied Physiology·T W Balon, J L Nadler

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Citations

Mar 16, 2011·Cardiology Research and Practice·Mário Raimundo, José António Lopes
Mar 4, 2003·Clinical and Experimental Hypertension : CHE·Sumangala P RaoJoseph C Dunbar
Aug 9, 2007·Journal of the Cardiometabolic Syndrome·Lydia Sebba Souza MariosaMaria Teresa Zanella
Oct 7, 2010·Journal of Diabetes·Xiongzhong Ruan, Youfei Guan
May 23, 2002·Hypertension·Caroline RhéaumeJean Cléroux
Apr 28, 2012·Diabetes & Metabolism Journal·Zhenqi LiuWenhong Cao
May 31, 2006·American Journal of Nephrology·Pantelis A Sarafidis, Luis M Ruilope
Jul 2, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D E LaaksonenL K Niskanen
May 26, 2007·Endocrine Reviews·Ranganath MuniyappaMichael J Quon
Jan 18, 2003·American Journal of Physiology. Endocrinology and Metabolism·Michael G ClarkStephen Rattigan
Apr 16, 2009·American Journal of Physiology. Endocrinology and Metabolism·Rodrigo P A BarrosJan-Ake Gustafsson

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