Insulin resistance in hidradenitis suppurativa: a case-control study

Journal of the European Academy of Dermatology and Venereology : JEADV
I VilanovaM A González-López

Abstract

The association between chronic inflammatory diseases, such as rheumatoid arthritis and psoriasis, and insulin resistance (IR) has been well established. Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease that affects the apocrine gland-bearing areas of the body. We aimed to determine the prevalence of IR in patients with HS. This cross-sectional, case-control study enrolled 137 subjects, 76 patients with HS and 61 age- and gender-matched controls. Demographic data, clinical examination of HS patients, anthropometric measures, cardiovascular risk factors and laboratory studies were recorded. The homeostasis model assessment of IR (HOMA-IR) was calculated in all participants by measuring fasting plasma glucose and insulin levels. The median (IQR) HOMA-IR value in HS patients was significantly higher [2.0 (1.0-3.6)] than in controls [1.5 (0.9-2.3)] (P = 0.01). The prevalence of IR was significantly higher in cases (43.4%) compared with controls (16.4%) (P = 0.001). In the linear regression multivariable analysis after adjusting for age, sex and body mass index (BMI), HS remained as a significant factor for a higher HOMA-IR [2.51 (0.18) vs 1.92(0.21); P = 0.04]. The HOMA-IR value and the prevalence of IR did...Continue Reading

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Citations

Jan 19, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·J Ring
Jan 9, 2019·Dermatologic Therapy·Burhan EnginServer Serdaroğlu
Oct 6, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·J L HernándezM A González-López
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Oct 6, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·C MarascaG Fabbrocini
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Oct 28, 2019·International Journal of Dermatology·Franchesca ChoiNatasha A Mesinkovska
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May 28, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·T V NguyenG B Jemec
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Jun 5, 2021·Experimental Dermatology·Christos C ZouboulisErrol P Prens
Jun 5, 2021·Experimental Dermatology·Christos C ZouboulisAngel S Byrd

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