PMID: 8581776Sep 1, 1995Paper

Insulin resistance in obesity and its molecular control

Obesity Research
T Noguchi, T Tanaka

Abstract

The Wistar fatty rat is a model of obese non-insulin-dependent diabetes mellitus. Males, but not females, develop hyperglycemia, glucouria and polyuria within 8 weeks of age. The regulation of gene expression by insulin has been shown to be differentially impaired in the liver of the fatty rats. The genes resistant to insulin include glucokinase gene and phosphoenolpyruvate carboxykinase gene. In contrast, L-type pyruvate kinase gene responds to insulin normally, raising the possibility that the signaling pathway from the insulin receptor to the insulin-resistant genes, but not to the insulin-sensitive genes, is defective at a point beyond the receptor kinase in the fatty rats. On the other hand, female fatty rats develop hyperglycemia only when they are given sucrose for several weeks. This treatment causes a decrease in gucokinase while enzymes involved in gluconeogenesis are increased. Chronic feeding of sucrose also leads to hypertriglycemia and visceral fat accumulation, which is more frequently associated with abnormalities in glucose and lipid metabolisms. Fructose is believed to be the responsible component of sucrose for these effects. Hypertriglyceridemic effect of fructose is mainly due to an increase in hepatic prod...Continue Reading

References

Jun 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·T NoguchiT Tanaka
Sep 26, 1991·The New England Journal of Medicine·D E Moller, J S Flier
Jan 1, 1986·Annual Review of Nutrition·R Levine
Sep 1, 1969·European Journal of Biochemistry·A SilleroA Sols
Dec 1, 1983·Journal of Nutritional Science and Vitaminology·H FukudaT Tanaka
Dec 1, 1981·Diabetes·H IkedaZ Suzuoki
Jun 1, 1982·Metabolism: Clinical and Experimental·T A TobeyG M Reaven

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Citations

Oct 4, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bethany P CummingsPeter J Havel
Feb 23, 2005·Nutrition & Metabolism·Heather BascianoKhosrow Adeli
May 18, 2010·The Journal of Nutritional Biochemistry·Maria E FrigoletArmando R Tovar
Jun 13, 2009·Comptes rendus biologies·Ugochukwu E Uzuegbu, Innocent Onyesom
Mar 24, 2009·Metabolism: Clinical and Experimental·Nathalie PamirRenée C LeBoeuf
Jul 21, 2011·European Journal of Clinical Nutrition·J C K Wells, M Siervo

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