PMID: 6991320Mar 1, 1980Paper

Insulin resistance in obesity as analyzed by the response of glucose kinetics to glucagon infusion

Diabetes
M VranicG Steiner

Abstract

A new approach has been developed to examine insulin sensitivity and resistance in vivo in man. In it, tracer methods are used, which permit the assessment of nonsteady state glucose kinetics by a method that is noninvasive and does not use pharmacologic agents. Graded doses of glucagon, infused intravenously, are used to drive glucose out of steady state and to stimulate the release of insulin into the portal circulation. By relating the changes in the rates of glucose production, utilization, and fractional disappearance to immunoreactive glucagon and insulin, it is possible to assess the body's sensitivity to physiologic levels of these two hormones. The utility of this approach was examined in obesity, a known human model of insulin resistance. The data demonstrated that glucose production in the obese subjects responded normally to glucagon. They also showed that insulin was much less effective in promoting glucose utilization in the obese persons than it was in the normal ones. In the obese subjects who were studied, the pancreatic B-cells were shown to be normally responsive to the stimulatory effects of either glucose or glucagon. Hence, they did not release sufficient insulin to overcome the insulin resistance, and the...Continue Reading

Citations

Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A WajngotS Efendić
Jun 1, 1985·Annals of Surgery·K R SirinekA S McFee
Jan 1, 1984·Critical Reviews in Clinical Laboratory Sciences·A M Bonser, P Garcia-Webb
Oct 1, 1991·Diabetes Research and Clinical Practice·S Zuniga-GuarjardoB Zinman
Jul 1, 1982·Clinics in Endocrinology and Metabolism·A D Cherrington, K E Steiner
Sep 9, 2010·American Journal of Physiology. Endocrinology and Metabolism·Mladen Vranic
May 1, 1981·The American Journal of Physiology·H L MinukB Zinman

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