Insulin resistance in patients with hypertrophic cardiomyopathy

Circulation Journal : Official Journal of the Japanese Circulation Society
Kazuo MurakamiJitsuo Higaki

Abstract

The aim of the present study was to investigate whether or not insulin resistance is present in hypertrophic cardiomyopathy (HCM), and also whether it is related to the clinical manifestations of HCM. The study group comprised 55 patients with HCM, 35 with essential hypertension (EHT) and 15 normotensive control subjects (NC). An insulin resistance index was estimated using the homeostasis model assessment (HOMA-IR) of fasting insulin - glucose interactions. In patients with HCM, prognosis and cardiovascular events were also checked. The HOMA-IR values in the HCM group (2.90+/-1.22) were significantly higher than those in the EHT (1.69+/-0.77) and NC groups (0.91+/-0.24). The HOMA-IR values in the EHT group were significantly higher than those in the NC group. Multiple regression analyses determined that left ventricular pressure gradient without provocation (p<0.0001), interventricular septal thickness (p=0.0143) and body mass index (p=0.0412) were independent determinants of insulin resistance in patients with HCM. During a mean follow-up of 105+/-50 months, 4 patients with HCM died suddenly and all of them had high HOMA-IR values. The results suggest that patients with HCM without apparent diabetes mellitus or hypertension h...Continue Reading

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Citations

Jun 21, 2014·Journal of Diabetes Research·M E HansenB T Bikman
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sayantani ChowdhuryParames C Sil
Nov 21, 2014·Journal of Veterinary Internal Medicine·L M FreemanI van Hoek
Sep 25, 2012·Journal of Feline Medicine and Surgery·Lisa M FreemanSuzanne M Cunningham
Feb 6, 2014·Molecular Genetics & Genomic Medicine·Tzipora C Falik ZaccaiEfrat Wertheimer
Dec 4, 2019·European Journal of Preventive Cardiology·Jun-Bean ParkHyung-Kwan Kim
Jan 19, 2021·European Journal of Pediatrics·Panjarat SowithayasakulHermann L Müller

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