Insulin resistance in patients with recurrent pregnancy loss is associated with lymphocyte population aberration

Systems Biology in Reproductive Medicine
Yan YanWeiyan Tu

Abstract

This study was designed to investigate the relationship of insulin resistance (IR) and cellular immune abnormalities associated with women with recurrent pregnancy loss (RPL). Women with RPL were divided into two groups according to their homeostasis model assessment for IR (HOMA-IR) scores. The IR group received metformin approximately 3 months before pregnancy. The percentage of lymphocyte subsets and other blood biochemical indices were tested. The HOMA-IR and fasting serum insulin levels were related to the percentage of lymphocyte subsets. The women with RPL had higher CD3+ and CD3+CD4+ cell levels while CD56+CD16+cell levels were lower. A higher likelihood of cellular immune abnormalities was observed. Women with normal lymphocyte subsets had normal pregnancy outcomes. Metformin significantly downregulated CD3+ and CD3+CD4+ cells and improved pregnancy outcomes. IR was associated with cellular immune abnormalities in RPL. The data suggests that metformin affected the immune/inflammatory response, which may regulate the cellular immune balance and improve pregnancy outcomes. Abbreviations RPL: recurrent pregnancy loss; IR insulin resistance; HOMA-IR: homeostasis model assessment for IR.

References

Mar 12, 2003·The Journal of Clinical Endocrinology and Metabolism·Jenny E GuntonRobert C Baxter
May 11, 2006·Human Reproduction·Xiaoli ChenLiangan Wang
Oct 25, 2008·European Journal of Medicinal Chemistry·T NarenderS C Agarwal
Apr 19, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Qiushi WangWei Huang
Sep 29, 2011·Clinical Endocrinology·Konstanze MiehleMathias Fasshauer
Nov 16, 2011·Nigerian Medical Journal : Journal of the Nigeria Medical Association·U ShankarkumarK Ghosh
Oct 26, 2012·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
Feb 15, 2013·American Journal of Reproductive Immunology : AJRI·Claudia Pérez Leirós, Rosanna Ramhorst
Feb 19, 2013·Diabetology & Metabolic Syndrome·Lilian Beatriz Aguayo Rojas, Marilia Brito Gomes
Apr 16, 2013·Reproductive Sciences·Tomi T KanninenSteven S Witkin
Sep 19, 2014·The Breast : Official Journal of the European Society of Mastology·Soley BayraktarBanu Arun
Mar 3, 2015·Expert Opinion on Therapeutic Targets·Neira SáinzMaria J Moreno-Aliaga
Jul 15, 2015·Taiwanese Journal of Obstetrics & Gynecology·Mawahib A S Al-Biate
Feb 18, 2016·Current Topics in Medicinal Chemistry·Malgorzata TomczynskaJoanna Saluk
Apr 7, 2016·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·M AljiffryP Metrakos
Apr 30, 2016·International Journal of Applied & Basic Medical Research·Ramandeep Kaur, Kapil Gupta
May 11, 2016·Cell Reports·Adam R KonopkaK Sreekumaran Nair
May 24, 2016·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Jin KumagaiToshinori Nakayama

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