Insulin resistance in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a new model of NIDDM

Diabetologia
T SatoN Nakayama

Abstract

The Otsuka Long-Evans Tokushima Fatty rat is a new inbred obese strain with a late onset and chronic course of spontaneous hyperglycaemia in the male, and is considered to be a model of non-insulin-dependent diabetes mellitus [1, 2]. Fat distribution analysis showed a typical accumulation of intra-abdominal visceral fat in Otsuka Long-Evans Tokushima Fatty rats compared with a control strain, Long-Evans Tokushima Otsuka rats. To examine the insulin sensitivity of Otsuka Long-Evans Tokushima Fatty rats, we performed euglycaemic hyperinsulinaemic clamp experiments in vivo in rats under anaesthesia on this strain and on Long-Evans Tokushima Otsuka rats. The Otsuka Long-Evans Tokushima Fatty rats showed lower values for the glucose infusion rate (60% of the control at 12 weeks old and 20-30% of the control at 18, 24, 30 and 39 weeks old) than age-matched controls, indicating the development of insulin resistance with age. Hindlimb perfusion experiments in vitro also showed a 45% decrease of insulin-stimulated glucose uptake in Otsuka Long-Evens Tokushima Fatty rats in the diabetic stage. These results indicate that insulin resistance exists in the skeletal muscle of Otsuka Long-Evans Tokushima Fatty rats. To obtain information on t...Continue Reading

References

Dec 1, 1991·Diabetes Care·P Björntorp
Sep 18, 1987·Science·O M Rosen
Jan 1, 1986·The Journal of Clinical Investigation·C F BurantM G Buse
Oct 1, 1988·The Journal of Clinical Investigation·C R Kahn, M F White
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D O MorganR A Roth

❮ Previous
Next ❯

Citations

Jan 4, 2001·Diabetes Research and Clinical Practice·J NakamuraN Hotta
Oct 1, 1996·Baillière's Clinical Endocrinology and Metabolism·S Robinson, C H Prendergast
Nov 25, 2000·The Journal of Nutritional Biochemistry·K S KimC H Kim
Nov 6, 2004·Nephron. Experimental Nephrology·Yoko FuruseYasushi Saito
Sep 11, 2012·Journal of Clinical Biochemistry and Nutrition·Ying-Ling LaiHiroshi Ohshima
May 26, 1998·Biochemical and Biophysical Research Communications·T OyaT Osawa
Mar 26, 2009·Journal of Gastroenterology·Hitoshi YoshijiHiroshi Fukui
Oct 3, 2003·Journal of Pineal Research·Shigeru NishidaShigeki Nakagawa
Jul 19, 2012·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Catherine R MikusJohn P Thyfault
Aug 30, 2008·Current Protocols in Stem Cell Biology·Eric C LarsenIan D Duncan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.