Insulin Resistance in South African Youth Living with Perinatally Acquired HIV Receiving Antiretroviral Therapy

AIDS Research and Human Retroviruses
Lisa FrigatiHeather J Zar

Abstract

To investigate the prevalence of and risk factors for insulin resistance (IR) in a cohort of youth living with perinatally acquired HIV (YLPHIV) receiving antiretroviral treatment (ART). A cross-sectional analysis of IR in YLPHIV and age-matched HIV-uninfected youth enrolled in the Cape Town Adolescent Antiretroviral Cohort. South African youth ages 9-14 years, with perinatally acquired HIV who were on ART for >6 months and age-matched HIV-uninfected adolescents, were eligible. The homeostatic model assessment of insulin resistance (HOMA-IR), calculated from fasting insulin and glucose measurements at enrollment, was used to assess IR. Multiple linear regression was used to examine adjusted associations between HOMA and HIV-related and traditional cardiovascular risk factors. Of 448 adolescents, 385 (85.9%) were YLPHIV; median age was 12.1 years [interquartile range (IQR): 10.8-13.5], and 50.4% were female. Median duration on ART was 7.5 (IQR: 4.5-9.2) years. The prevalence of IR in YLPHIV was 18%. Among YLPHIV, waist circumference (ß = 0.01, p = .01), hypertriglyceridemia (ß = 0.07, p = .01), CD4 count >500 cells/mm3 (ß = 0.08, p = .02), or prior use of abacavir (ß = 0.06, p = .04) were associated with increased HOMA, after ad...Continue Reading

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Citations

Apr 15, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sana MahtabJennifer Jao
Aug 24, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhe-Bin ChengChi Zhang
Jul 23, 2021·The Pediatric Infectious Disease Journal·Michela Masi-LeoneJennifer Jao
Oct 16, 2021·Current HIV/AIDS Reports·Sahera Dirajlal-Fargo, Grace A McComsey

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