Insulin resistance is associated with all chronic complications in type 1 diabetes

Journal of Diabetes
Andrei PopRomDiane Study Group

Abstract

Insulin resistance (IR) is present in type 1 diabetes mellitus (T1DM) and is suggested to be related to chronic diabetic complications. The primary aim of our study was to assess IR in T1DM patients with and without chronic complications. A secondary aim was to evaluate the possible association between IR and chronic diabetic complications. This cross-sectional study enrolled 272 patients with T1DM. Insulin resistance was quantified using the estimated glucose disposal rate (eGDR). Associations between eGDR and each diabetes complication were first evaluated using binary logistic regression, then multiparametric logistic regression with stepwise selection of covariates. The discriminative value of eGDR was assessed by receiver operating characteristic (ROC) curve analysis. Estimated GDR was lower in patients with chronic diabetic complications (6.1 vs 6.9 mg/kg per min [P = 0.02] for retinopathy; 6.3 vs 7.3 mg/kg per min [P < 0.01] for nephropathy; 6.5 vs 7.6 mg/kg per min [P < 0.01] for neuropathy; and 5.2 vs 7.5 mg/kg per min [P < 0.01] for cardiovascular complications). In univariate analysis eGDR was associated all diabetic complications. These associations remained significant after adjustment for different variables in th...Continue Reading

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Citations

Jun 2, 2016·BioMed Research International·Shoko HoritaGeorge Seki
Apr 11, 2017·Metabolic Syndrome and Related Disorders·Pawel NiedzwieckiDorota Zozulinska-Ziolkiewicz
Jul 19, 2018·Muscle & Nerve·Pinar GencpinarHilmi Uysal
Jan 18, 2018·BMC Endocrine Disorders·Selvihan BeyselErman Cakal
Dec 4, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Diana ŠimonienėDžilda Veličkiene
May 27, 2020·Diabetes/metabolism Research and Reviews·Rosana Cristina MoriMaria Lúcia Correa-Giannella
Dec 13, 2017·Diabetes/metabolism Research and Reviews·Brett RydzonKirstie K Danielson
Dec 30, 2015·Romanian Journal of Internal Medicine = Revue Roumaine De Médecine Interne·Irina DuţăDaniela Adriana Ion
May 3, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Mikołaj KamińskiDorota Zozulińska-Ziółkiewicz

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